Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
Baicalin and baicalein are the primary flavonoids derived from the desiccated root of Scutellaria baicalensis, which is a member of the Lamiaceae family; these flavonoids have diverse pharmacological properties and show significant potential for the management of central nervous system disorders. Mu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024170338 |
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| author | Lujia Si Yupu An Jiahang Zhou Yu Lai |
| author_facet | Lujia Si Yupu An Jiahang Zhou Yu Lai |
| author_sort | Lujia Si |
| collection | DOAJ |
| description | Baicalin and baicalein are the primary flavonoids derived from the desiccated root of Scutellaria baicalensis, which is a member of the Lamiaceae family; these flavonoids have diverse pharmacological properties and show significant potential for the management of central nervous system disorders. Multiple studies have indicated that these substances effectively reduce the severity of illnesses such as depression, stroke, and degenerative disorders of the central nervous system by exerting antioxidant and anti-inflammatory effects, regulating programmed cell death, and reducing mitochondrial malfunction. Recent studies have highlighted the connection between the accumulation of iron and the ability of baicalein to protect the nervous system. Given the diverse therapeutic effects of baicalein, this review aims to thoroughly investigate the regulatory pharmacological mechanisms through which baicalein influences the development of central nervous system disorders. By elucidating these mechanisms, this review contributes to the development of therapeutic approaches that target disorders of the central nervous system. |
| format | Article |
| id | doaj-art-b667e7b6e353433d88a0c6fa6e7ac85d |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-b667e7b6e353433d88a0c6fa6e7ac85d2025-01-17T04:49:58ZengElsevierHeliyon2405-84402025-01-01111e41002Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanismsLujia Si0Yupu An1Jiahang Zhou2Yu Lai3Acupunture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupunture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Humanities and Social Sciences, North University of China, Taiyuan, ChinaSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Corresponding author. No. 1166 Liutai Avenue, Chengdu, 611137, China.Baicalin and baicalein are the primary flavonoids derived from the desiccated root of Scutellaria baicalensis, which is a member of the Lamiaceae family; these flavonoids have diverse pharmacological properties and show significant potential for the management of central nervous system disorders. Multiple studies have indicated that these substances effectively reduce the severity of illnesses such as depression, stroke, and degenerative disorders of the central nervous system by exerting antioxidant and anti-inflammatory effects, regulating programmed cell death, and reducing mitochondrial malfunction. Recent studies have highlighted the connection between the accumulation of iron and the ability of baicalein to protect the nervous system. Given the diverse therapeutic effects of baicalein, this review aims to thoroughly investigate the regulatory pharmacological mechanisms through which baicalein influences the development of central nervous system disorders. By elucidating these mechanisms, this review contributes to the development of therapeutic approaches that target disorders of the central nervous system.http://www.sciencedirect.com/science/article/pii/S2405844024170338BaicalinBaicaleinNeuroprotectionStrokeParkinson's disease |
| spellingShingle | Lujia Si Yupu An Jiahang Zhou Yu Lai Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms Heliyon Baicalin Baicalein Neuroprotection Stroke Parkinson's disease |
| title | Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms |
| title_full | Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms |
| title_fullStr | Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms |
| title_full_unstemmed | Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms |
| title_short | Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms |
| title_sort | neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms |
| topic | Baicalin Baicalein Neuroprotection Stroke Parkinson's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024170338 |
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