Micronutrient antioxidant supplementation alleviates valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway

Micronutrient antioxidant supplementation alleviates valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway

Background: Valproic Acid (VPA), a widely used anticonvulsant, is known to induce oxidative stress, contributing to male infertility. This study explores the potential of micronutrient antioxidants to improve fertility in VPA-treated individuals. Methods: Six-week-old male mice were treated with VPA...

Full description

Saved in:
Bibliographic Details
Main Authors: Muhammad Arif Asghar, Bing Wan, Lu Li, Jie Zhang, Shixin Tang, Hang Han, Yuanyuan Yang, Long Chu, Qian Zhang, Xiao Zhang, Qinjian Zhao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Valproic acid-induced infertility
NRF2/HO-1 pathway
Micronutrient antioxidants
Oxidative stress
GC-2spd(ts) and HepG2 cells
Network pharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001983
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2213231725001983

Similar Items