Association of FV G1691A, FV H1299R, and FII G20210A variations with thrombosis and coronary artery disease (CAD): A population-based study
Background: Thrombosis and coronary artery disease (CAD) are complex disorders influenced by genetic factors. Specific gene variations, such as Factor V (FV) G1691A (Leiden), FV H1299R, and Prothrombin (FII) G20210A, have been implicated in thrombotic events and CAD. However, their precise role in C...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| author | Ünallı Özmen Sevda Özarda Yeşim Köseler Aylin Sabırlı Ramazan Kaynak Derya Sucu Koç Ibrahim |
| author_facet | Ünallı Özmen Sevda Özarda Yeşim Köseler Aylin Sabırlı Ramazan Kaynak Derya Sucu Koç Ibrahim |
| author_sort | Ünallı Özmen Sevda |
| collection | DOAJ |
| description | Background: Thrombosis and coronary artery disease (CAD) are complex disorders influenced by genetic factors. Specific gene variations, such as Factor V (FV) G1691A (Leiden), FV H1299R, and Prothrombin (FII) G20210A, have been implicated in thrombotic events and CAD. However, their precise role in CAD development remains controversial. This study investigated the prevalence and association of these gene variations with thrombosis and CAD in the Turkish population. Methods: A case-control study included 406 healthy individuals and 64 CAD patients. Genotyping for FV G1691A, FV H1299R, and FII G20210A was performed using a strip assay. Fisher's exact test compared allele and genotype frequencies between the CAD and control groups. Results: No significant differences were observed in genotype frequencies of FV G1691A, FV H1299R, and FII G20210A between the CAD and control groups (p>0.05). Similarly, allele frequencies did not differ significantly between the two groups (p>0.05). Conclusions: The findings suggest that FV G1691A, FV H1299R, and FII G20210A variations may not play a significant role in the development of CAD in the Turkish population studied. These results are consistent with the existing conflicting literature on the association between these gene variations and CAD. Further research with larger sample sizes and diverse populations is warranted to elucidate the role of these variations in CAD pathogenesis. |
| format | Article |
| id | doaj-art-b64cb133f17a4be2bb29c10753bdd7f5 |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-b64cb133f17a4be2bb29c10753bdd7f52025-08-20T03:50:12ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144344745210.5937/jomb0-396681452-82582503447QAssociation of FV G1691A, FV H1299R, and FII G20210A variations with thrombosis and coronary artery disease (CAD): A population-based studyÜnallı Özmen Sevda0Özarda Yeşim1Köseler Aylin2Sabırlı Ramazan3Kaynak Derya Sucu4Koç Ibrahim5City Hospıtal, Central Laboratory, Department of Medical Biochemistry Bursa, TurkeyYeditepe Unıversity, Faculty of Medicine, Department of Medical Biochemistry, Istanbul, TurkeyPamukkale University, Faculty of Medicine, Department of Biophysics, Denizli, TurkeyServergazi State Hospital, Department of Emergency Medicine, Denizli, TurkeyHead Office, Department of Occupational Health and Safety Specialist, Bursa, TurkeyCity Hospıtal, Department of Pulmonary Medicine Clinic, Bursa, TurkeyBackground: Thrombosis and coronary artery disease (CAD) are complex disorders influenced by genetic factors. Specific gene variations, such as Factor V (FV) G1691A (Leiden), FV H1299R, and Prothrombin (FII) G20210A, have been implicated in thrombotic events and CAD. However, their precise role in CAD development remains controversial. This study investigated the prevalence and association of these gene variations with thrombosis and CAD in the Turkish population. Methods: A case-control study included 406 healthy individuals and 64 CAD patients. Genotyping for FV G1691A, FV H1299R, and FII G20210A was performed using a strip assay. Fisher's exact test compared allele and genotype frequencies between the CAD and control groups. Results: No significant differences were observed in genotype frequencies of FV G1691A, FV H1299R, and FII G20210A between the CAD and control groups (p>0.05). Similarly, allele frequencies did not differ significantly between the two groups (p>0.05). Conclusions: The findings suggest that FV G1691A, FV H1299R, and FII G20210A variations may not play a significant role in the development of CAD in the Turkish population studied. These results are consistent with the existing conflicting literature on the association between these gene variations and CAD. Further research with larger sample sizes and diverse populations is warranted to elucidate the role of these variations in CAD pathogenesis.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582503447Q.pdfthrombosiscoronary artery diseasefactor v geneprothrombin genegene variationsallele frequencies |
| spellingShingle | Ünallı Özmen Sevda Özarda Yeşim Köseler Aylin Sabırlı Ramazan Kaynak Derya Sucu Koç Ibrahim Association of FV G1691A, FV H1299R, and FII G20210A variations with thrombosis and coronary artery disease (CAD): A population-based study Journal of Medical Biochemistry thrombosis coronary artery disease factor v gene prothrombin gene gene variations allele frequencies |
| title | Association of FV G1691A, FV H1299R, and FII G20210A variations with thrombosis and coronary artery disease (CAD): A population-based study |
| title_full | Association of FV G1691A, FV H1299R, and FII G20210A variations with thrombosis and coronary artery disease (CAD): A population-based study |
| title_fullStr | Association of FV G1691A, FV H1299R, and FII G20210A variations with thrombosis and coronary artery disease (CAD): A population-based study |
| title_full_unstemmed | Association of FV G1691A, FV H1299R, and FII G20210A variations with thrombosis and coronary artery disease (CAD): A population-based study |
| title_short | Association of FV G1691A, FV H1299R, and FII G20210A variations with thrombosis and coronary artery disease (CAD): A population-based study |
| title_sort | association of fv g1691a fv h1299r and fii g20210a variations with thrombosis and coronary artery disease cad a population based study |
| topic | thrombosis coronary artery disease factor v gene prothrombin gene gene variations allele frequencies |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582503447Q.pdf |
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