Correlation of Different Non-Invasive Neuromonitoring Tools Assessing Intracranial Hemodynamics
Background: Intracranial pressure (ICP) monitoring is crucial in managing acute brain injury (ABI) to prevent secondary brain injury. While invasive techniques remain the gold standard, they can carry notable risks, such as infection and hemorrhage. Non-invasive techniques are increasingly used, but...
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2025-06-01
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| author | Rossella Zangari Luca D’Amelio Elisa Gouvea Bogossian Fabio Silvio Taccone |
| author_facet | Rossella Zangari Luca D’Amelio Elisa Gouvea Bogossian Fabio Silvio Taccone |
| author_sort | Rossella Zangari |
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| description | Background: Intracranial pressure (ICP) monitoring is crucial in managing acute brain injury (ABI) to prevent secondary brain injury. While invasive techniques remain the gold standard, they can carry notable risks, such as infection and hemorrhage. Non-invasive techniques are increasingly used, but their inter-modality correlation and concordance have not been systematically evaluated. This study aimed to assess the correlation and concordance among four commonly used non-invasive neuromonitoring tools in patients with ABI undergoing invasive ICP monitoring. Methods: This was a secondary analysis of prospectively collected data from 100 adult patients admitted to the intensive care unit with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), or intracerebral hemorrhage (ICH) who underwent invasive ICP monitoring. Simultaneous assessments using optic nerve sheath diameter (ONSD), transcranial Doppler-derived pulsatility index (PI), estimated ICP (eICP), and the neurological pupil index (NPi) were performed. Correlation between modalities was assessed using Spearman’s correlation coefficient (ρ), and concordance was evaluated with Cohen’s kappa coefficient (k). Results: We found weak correlations between ONSD and PI (ρ = 0.29), ONSD and NPi (ρ = −0.33), and PI and NPi (ρ = −0.33); moderate correlations between ONSD and eICP (ρ = 0.54) and PI and eICP (ρ = 0.48); and a strong inverse correlation between eICP and NPi (ρ = −0.71; all <i>p</i> < 0.05). Concordance was generally low, with the highest agreement between PI and eICP (k = 0.69). Most other tool pairings showed poor-to-fair concordance (k ≤ 0.30). Conclusions: Non-invasive neuromonitoring tools show variable correlation and limited agreement, suggesting they are not interchangeable. Each modality captures different aspects of cerebral physiology, supporting the use of a multimodal approach to improve accuracy in ICP estimation. |
| format | Article |
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| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj-art-b643db8f77a24e24a9efcd349fdac04b2025-08-20T03:58:26ZengMDPI AGBrain Sciences2076-34252025-06-0115771010.3390/brainsci15070710Correlation of Different Non-Invasive Neuromonitoring Tools Assessing Intracranial HemodynamicsRossella Zangari0Luca D’Amelio1Elisa Gouvea Bogossian2Fabio Silvio Taccone3Department of Intensive Care and Emergency, Spedali Civili di Brescia, Università degli Studi di Brescia, 25121 Brescia, ItalyDepartment of Intensive Care, Route de Lennik, Erasme Hospital, Université Libre de Bruxelles, 808, 1070 Brussels, BelgiumDepartment of Intensive Care, Route de Lennik, Erasme Hospital, Université Libre de Bruxelles, 808, 1070 Brussels, BelgiumDepartment of Intensive Care, Route de Lennik, Erasme Hospital, Université Libre de Bruxelles, 808, 1070 Brussels, BelgiumBackground: Intracranial pressure (ICP) monitoring is crucial in managing acute brain injury (ABI) to prevent secondary brain injury. While invasive techniques remain the gold standard, they can carry notable risks, such as infection and hemorrhage. Non-invasive techniques are increasingly used, but their inter-modality correlation and concordance have not been systematically evaluated. This study aimed to assess the correlation and concordance among four commonly used non-invasive neuromonitoring tools in patients with ABI undergoing invasive ICP monitoring. Methods: This was a secondary analysis of prospectively collected data from 100 adult patients admitted to the intensive care unit with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), or intracerebral hemorrhage (ICH) who underwent invasive ICP monitoring. Simultaneous assessments using optic nerve sheath diameter (ONSD), transcranial Doppler-derived pulsatility index (PI), estimated ICP (eICP), and the neurological pupil index (NPi) were performed. Correlation between modalities was assessed using Spearman’s correlation coefficient (ρ), and concordance was evaluated with Cohen’s kappa coefficient (k). Results: We found weak correlations between ONSD and PI (ρ = 0.29), ONSD and NPi (ρ = −0.33), and PI and NPi (ρ = −0.33); moderate correlations between ONSD and eICP (ρ = 0.54) and PI and eICP (ρ = 0.48); and a strong inverse correlation between eICP and NPi (ρ = −0.71; all <i>p</i> < 0.05). Concordance was generally low, with the highest agreement between PI and eICP (k = 0.69). Most other tool pairings showed poor-to-fair concordance (k ≤ 0.30). Conclusions: Non-invasive neuromonitoring tools show variable correlation and limited agreement, suggesting they are not interchangeable. Each modality captures different aspects of cerebral physiology, supporting the use of a multimodal approach to improve accuracy in ICP estimation.https://www.mdpi.com/2076-3425/15/7/710acute brain injuryintracranial hypertensioncerebral blood flowcerebral perfusion pressuretranscranial Doppler ultrasonographyneuromonitoring |
| spellingShingle | Rossella Zangari Luca D’Amelio Elisa Gouvea Bogossian Fabio Silvio Taccone Correlation of Different Non-Invasive Neuromonitoring Tools Assessing Intracranial Hemodynamics Brain Sciences acute brain injury intracranial hypertension cerebral blood flow cerebral perfusion pressure transcranial Doppler ultrasonography neuromonitoring |
| title | Correlation of Different Non-Invasive Neuromonitoring Tools Assessing Intracranial Hemodynamics |
| title_full | Correlation of Different Non-Invasive Neuromonitoring Tools Assessing Intracranial Hemodynamics |
| title_fullStr | Correlation of Different Non-Invasive Neuromonitoring Tools Assessing Intracranial Hemodynamics |
| title_full_unstemmed | Correlation of Different Non-Invasive Neuromonitoring Tools Assessing Intracranial Hemodynamics |
| title_short | Correlation of Different Non-Invasive Neuromonitoring Tools Assessing Intracranial Hemodynamics |
| title_sort | correlation of different non invasive neuromonitoring tools assessing intracranial hemodynamics |
| topic | acute brain injury intracranial hypertension cerebral blood flow cerebral perfusion pressure transcranial Doppler ultrasonography neuromonitoring |
| url | https://www.mdpi.com/2076-3425/15/7/710 |
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