Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity.
<h4>Introduction</h4>This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training...
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Public Library of Science (PLoS)
2025-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0313759 |
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| author | Pau Soldevila-Matías Joan Vicent Sánchez-Ortí Patricia Correa-Ghisays Vicent Balanzá-Martínez Gabriel Selva-Vera Roberto Sanchis-Sanchis Néstor Iglesias-García Manuel Monfort-Pañego Pilar Tomás-Martínez Víctor M Victor Benedicto Crespo-Facorro Constanza San Martin Valenzuela José Antonio Climent-Sánchez Rosana Corral-Márquez Inmaculada Fuentes-Durá Rafael Tabarés-Seisdedos |
| author_facet | Pau Soldevila-Matías Joan Vicent Sánchez-Ortí Patricia Correa-Ghisays Vicent Balanzá-Martínez Gabriel Selva-Vera Roberto Sanchis-Sanchis Néstor Iglesias-García Manuel Monfort-Pañego Pilar Tomás-Martínez Víctor M Victor Benedicto Crespo-Facorro Constanza San Martin Valenzuela José Antonio Climent-Sánchez Rosana Corral-Márquez Inmaculada Fuentes-Durá Rafael Tabarés-Seisdedos |
| author_sort | Pau Soldevila-Matías |
| collection | DOAJ |
| description | <h4>Introduction</h4>This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders and obesity comorbid using a longitudinal design and transdiagnostic perspective.<h4>Methods</h4>Patients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid obesity (n = 29) were assigned to a 12-week structured physical exercise program. Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. Maximum heart rate was considered a marker of effectiveness of physical activity. Mixed one-way analysis of variance and linear regression analyses were performed.<h4>Results</h4>Individuals with psychiatric disorders and comorbid obesity exhibited an improvement in cognition, mood symptoms and body mass index, increase anti-inflammatory activity together with enhancement of the oxidative and cardiovascular mechanisms after physical activity training (p<0.05 to 0.0001; d = 0.47 to 1.63). A better clinical outcomes along with regulation of inflammatory, oxidative, and cardiovascular mechanisms were critical for predicting significant maximum heart rate variation over time (χ2 = 32.2 to 39.0, p < 0.0001).<h4>Conclusions</h4>The regulation of the anti-inflammatory mechanisms may be essential for maintained of healthy physical activity across psychiatric disorders and obesity. Likewise, inflammatory activity, oxidative stress, vascular and cardio-metabolic mechanisms may be a useful to identify individuals at greater risk of multi-comorbidity. |
| format | Article |
| id | doaj-art-b6432a5fc6364c9cbf0cd7793d0a20cd |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-b6432a5fc6364c9cbf0cd7793d0a20cd2025-01-08T05:31:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031375910.1371/journal.pone.0313759Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity.Pau Soldevila-MatíasJoan Vicent Sánchez-OrtíPatricia Correa-GhisaysVicent Balanzá-MartínezGabriel Selva-VeraRoberto Sanchis-SanchisNéstor Iglesias-GarcíaManuel Monfort-PañegoPilar Tomás-MartínezVíctor M VictorBenedicto Crespo-FacorroConstanza San Martin ValenzuelaJosé Antonio Climent-SánchezRosana Corral-MárquezInmaculada Fuentes-DuráRafael Tabarés-Seisdedos<h4>Introduction</h4>This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders and obesity comorbid using a longitudinal design and transdiagnostic perspective.<h4>Methods</h4>Patients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid obesity (n = 29) were assigned to a 12-week structured physical exercise program. Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. Maximum heart rate was considered a marker of effectiveness of physical activity. Mixed one-way analysis of variance and linear regression analyses were performed.<h4>Results</h4>Individuals with psychiatric disorders and comorbid obesity exhibited an improvement in cognition, mood symptoms and body mass index, increase anti-inflammatory activity together with enhancement of the oxidative and cardiovascular mechanisms after physical activity training (p<0.05 to 0.0001; d = 0.47 to 1.63). A better clinical outcomes along with regulation of inflammatory, oxidative, and cardiovascular mechanisms were critical for predicting significant maximum heart rate variation over time (χ2 = 32.2 to 39.0, p < 0.0001).<h4>Conclusions</h4>The regulation of the anti-inflammatory mechanisms may be essential for maintained of healthy physical activity across psychiatric disorders and obesity. Likewise, inflammatory activity, oxidative stress, vascular and cardio-metabolic mechanisms may be a useful to identify individuals at greater risk of multi-comorbidity.https://doi.org/10.1371/journal.pone.0313759 |
| spellingShingle | Pau Soldevila-Matías Joan Vicent Sánchez-Ortí Patricia Correa-Ghisays Vicent Balanzá-Martínez Gabriel Selva-Vera Roberto Sanchis-Sanchis Néstor Iglesias-García Manuel Monfort-Pañego Pilar Tomás-Martínez Víctor M Victor Benedicto Crespo-Facorro Constanza San Martin Valenzuela José Antonio Climent-Sánchez Rosana Corral-Márquez Inmaculada Fuentes-Durá Rafael Tabarés-Seisdedos Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity. PLoS ONE |
| title | Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity. |
| title_full | Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity. |
| title_fullStr | Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity. |
| title_full_unstemmed | Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity. |
| title_short | Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity. |
| title_sort | clinical outcomes and anti inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity |
| url | https://doi.org/10.1371/journal.pone.0313759 |
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