Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties
The antioxidant properties of novel diiodo-substituted 3-dithiocarbamic flavanones were investigated. The three frameworks that proved to be the most active ones in our previous studies were selected. By varying the nature of the substituent at the para position of flavanone ring <b>B</b>...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/11/2280 |
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| Summary: | The antioxidant properties of novel diiodo-substituted 3-dithiocarbamic flavanones were investigated. The three frameworks that proved to be the most active ones in our previous studies were selected. By varying the nature of the substituent at the para position of flavanone ring <b>B</b>, a structure–activity relationship study on radical scavenging properties was performed. The influence of these substituents (F, Cl, Br and H) was investigated against DPPH and ABTS<sup>+•</sup>. The results indicate that the presence of the halogen substituents induces better antioxidant properties than ascorbic acid and BHT. The highest radical scavenging activity was found in the case of morpholine carbodithioates. Regarding the ABTS<sup>+•</sup> assay, all investigated flavanones exhibited better antioxidant properties than BHT. |
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| ISSN: | 1420-3049 |