Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3

Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3

Summary: Impaired β cell function is a hallmark of type 2 diabetes (T2D), but the underlying cellular signaling machineries that regulate β cell function remain unknown. Here, we identify that the interleukin-22 receptor subunit alpha 1 (IL-22RA1), known as a co-receptor for IL-22, is downregulated...

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Main Authors: Fan Yu, Shuting Xie, Tongyu Wang, Yeping Huang, Hong Zhang, Danfeng Peng, Yifan Feng, Yumei Yang, Zheyu Zhang, Yunxia Zhu, Zhuoxian Meng, Rong Zhang, Xiaomu Li, Hao Yin, Jie Xu, Cheng Hu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724014086
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