Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria
Introduction. Recent data have emerged about a protective association between JCV viruria and chronic kidney disease (CKD). Material and Methods. Single-center retrospective cohort study; 230 living kidney donors (LKD) candidates and 59 potential living kidney receptors (LKR) were enrolled. Plasma a...
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Wiley
2021-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2021/8010144 |
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| author | Sara Querido Carolina Ormonde Teresa Adragão Inês Costa Maria Ana Pessanha Perpétua Gomes André Weigert |
| author_facet | Sara Querido Carolina Ormonde Teresa Adragão Inês Costa Maria Ana Pessanha Perpétua Gomes André Weigert |
| author_sort | Sara Querido |
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| description | Introduction. Recent data have emerged about a protective association between JCV viruria and chronic kidney disease (CKD). Material and Methods. Single-center retrospective cohort study; 230 living kidney donors (LKD) candidates and 59 potential living kidney receptors (LKR) were enrolled. Plasma and urinary JCV and BKV viral loads were measured in all LKD candidates and in nonanuric LKR candidates. Twenty-six living kidney transplant surgeries were performed. LKR were followed in order to evaluate BKV and JCV viremia and urinary viral shedding after KT. Results. In LKD candidates, JCV viruria was negatively associated with proteinuria of >200 mg/24 hours (JC viruric LKD: 12.5% vs JCV nonviruric LKD: 26.7%, p=0.021, OR:0.393; 95% CI: 0.181–0.854). In a multivariate analysis, LKD candidates with JCV viruria had a lower risk of proteinuria of >200 mg/24 hours (p=0.009, OR: 0.342, 95% CI: 0.153–0.764), in a model adjusted for age, gender, presence of hypertension, and eGFR <80 mL/min. Prevalence of JCV viruria was higher in LKD candidates when compared with LKR candidates (40.0% vs 1.7%, p<0.001). Among the 26 LKR, 14 (53.8%) KT patients evolved with JCV viruria; 71.4% received a graft from a JCV viruric donor. Conclusion. Our data corroborate the recent findings of an eventual protective association between JCV viruria and kidney disease, and we extrapolated this concept to a South European population. |
| format | Article |
| id | doaj-art-b5d0d6338e7744d99cad77fa45b24a5f |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | International Journal of Nephrology |
| spelling | doaj-art-b5d0d6338e7744d99cad77fa45b24a5f2025-02-03T07:23:30ZengWileyInternational Journal of Nephrology2090-214X2090-21582021-01-01202110.1155/2021/80101448010144Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus ViruriaSara Querido0Carolina Ormonde1Teresa Adragão2Inês Costa3Maria Ana Pessanha4Perpétua Gomes5André Weigert6Department of Nephrology, Unit of Renal Transplantation, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Carnaxide, PortugalDepartment of Nephrology, Hospital do Divino Espírito Santo, Ponta Delgada, PortugalDepartment of Nephrology, Unit of Renal Transplantation, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Carnaxide, PortugalDepartment of Clinical Pathology, Laboratory of Clinical Microbiology and Molecular Biology, Centro Hospitalar de Lisboa Ocidental, Lisboa, PortugalDepartment of Clinical Pathology, Laboratory of Clinical Microbiology and Molecular Biology, Centro Hospitalar de Lisboa Ocidental, Lisboa, PortugalDepartment of Clinical Pathology, Laboratory of Clinical Microbiology and Molecular Biology, Centro Hospitalar de Lisboa Ocidental, Lisboa, PortugalDepartment of Nephrology, Unit of Renal Transplantation, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Carnaxide, PortugalIntroduction. Recent data have emerged about a protective association between JCV viruria and chronic kidney disease (CKD). Material and Methods. Single-center retrospective cohort study; 230 living kidney donors (LKD) candidates and 59 potential living kidney receptors (LKR) were enrolled. Plasma and urinary JCV and BKV viral loads were measured in all LKD candidates and in nonanuric LKR candidates. Twenty-six living kidney transplant surgeries were performed. LKR were followed in order to evaluate BKV and JCV viremia and urinary viral shedding after KT. Results. In LKD candidates, JCV viruria was negatively associated with proteinuria of >200 mg/24 hours (JC viruric LKD: 12.5% vs JCV nonviruric LKD: 26.7%, p=0.021, OR:0.393; 95% CI: 0.181–0.854). In a multivariate analysis, LKD candidates with JCV viruria had a lower risk of proteinuria of >200 mg/24 hours (p=0.009, OR: 0.342, 95% CI: 0.153–0.764), in a model adjusted for age, gender, presence of hypertension, and eGFR <80 mL/min. Prevalence of JCV viruria was higher in LKD candidates when compared with LKR candidates (40.0% vs 1.7%, p<0.001). Among the 26 LKR, 14 (53.8%) KT patients evolved with JCV viruria; 71.4% received a graft from a JCV viruric donor. Conclusion. Our data corroborate the recent findings of an eventual protective association between JCV viruria and kidney disease, and we extrapolated this concept to a South European population.http://dx.doi.org/10.1155/2021/8010144 |
| spellingShingle | Sara Querido Carolina Ormonde Teresa Adragão Inês Costa Maria Ana Pessanha Perpétua Gomes André Weigert Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria International Journal of Nephrology |
| title | Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria |
| title_full | Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria |
| title_fullStr | Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria |
| title_full_unstemmed | Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria |
| title_short | Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria |
| title_sort | outcomes of living kidney donor candidates and living kidney recipient candidates with jc polyomavirus and bk polyomavirus viruria |
| url | http://dx.doi.org/10.1155/2021/8010144 |
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