Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance

Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance

Abstract The resistance of pests to common insecticides is a global issue that threatens food production worldwide. Diamide insecticides target insect ryanodine receptors (RyRs), causing uncontrolled calcium release from the sarcoplasmic and endoplasmic reticulum. Despite their high potency and spec...

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Bibliographic Details
Main Authors: Lianyun Lin, Changshi Wang, Wenlan Wang, Heng Jiang, Takashi Murayama, Takuya Kobayashi, Hadiatullah Hadiatullah, Yu Seby Chen, Shunfan Wu, Yiwen Wang, Henryk Korza, Yucheng Gu, Yan Zhang, Jiamu Du, Filip Van Petegem, Zhiguang Yuchi
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53490-0
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