COVID-19 Vaccines: A Ray of Hope
Coronavirus-induced disease (COVID-19) has emerged as a dreaded pandemic which is a threat to the entire world. It all began in Wuhan, China, in December 2019 and rapidly spread over the world. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is an enveloped virus s...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-10-01
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| Series: | Indian Journal of Medical Specialities |
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| Online Access: | https://journals.lww.com/10.4103/injms.injms_86_21 |
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| author | Neha Chand Rajani Mathur Shridhar Dwivedi |
| author_facet | Neha Chand Rajani Mathur Shridhar Dwivedi |
| author_sort | Neha Chand |
| collection | DOAJ |
| description | Coronavirus-induced disease (COVID-19) has emerged as a dreaded pandemic which is a threat to the entire world. It all began in Wuhan, China, in December 2019 and rapidly spread over the world. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is an enveloped virus single-stranded, positive-sensed ribonucleic acid virus that enters the host cell lungs via endocytosis or membrane fusion utilizing the ACE-2 receptor. The virus particles release and replicate into new progenies, which cause cytokine storm in some cases by releasing pro-inflammatory mediators into the lungs. It dominantly manifests as SARS-CoV-2 and eventually involves all systems of human body. As of July 15, 2021, approximately 189 million COVID-19-infected cases have been reported worldwide, with over 4 million individuals dying as a result. In India, so far there are approximately 31 million infected cases and 4 lakhs human lives have been lost. Various antivirals, antibiotics, corticosteroids, and other adjuvant therapies were being experimentally employed for COVID-19 prophylaxis and treatment. Many pharmaceutical companies have worked on COVID-19 vaccinations to stop the virus progression and transmission. In several countries, including India, the United States, and Russia, the COVID-19 vaccine has already been approved for human use. India has been able to produce two vaccines, namely Covaxin and Covishield, and launches a massive vaccination drive for people above 18 years adults. Till now, approximately 304 million subjects have been partially vaccinated and 73 million subjects are fully vaccinated. Various other COVID-19 vaccines are in Phase 3 of clinical development. Vaccines against COVID are a major tool against the progression and prevention of COVID-19. |
| format | Article |
| id | doaj-art-b5c88a0bbdd445dbac5ca66cf54a9cd4 |
| institution | Kabale University |
| issn | 0976-2884 0976-2892 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Specialities |
| spelling | doaj-art-b5c88a0bbdd445dbac5ca66cf54a9cd42025-08-25T08:38:03ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Specialities0976-28840976-28922021-10-0112418819310.4103/injms.injms_86_21COVID-19 Vaccines: A Ray of HopeNeha ChandRajani MathurShridhar DwivediCoronavirus-induced disease (COVID-19) has emerged as a dreaded pandemic which is a threat to the entire world. It all began in Wuhan, China, in December 2019 and rapidly spread over the world. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is an enveloped virus single-stranded, positive-sensed ribonucleic acid virus that enters the host cell lungs via endocytosis or membrane fusion utilizing the ACE-2 receptor. The virus particles release and replicate into new progenies, which cause cytokine storm in some cases by releasing pro-inflammatory mediators into the lungs. It dominantly manifests as SARS-CoV-2 and eventually involves all systems of human body. As of July 15, 2021, approximately 189 million COVID-19-infected cases have been reported worldwide, with over 4 million individuals dying as a result. In India, so far there are approximately 31 million infected cases and 4 lakhs human lives have been lost. Various antivirals, antibiotics, corticosteroids, and other adjuvant therapies were being experimentally employed for COVID-19 prophylaxis and treatment. Many pharmaceutical companies have worked on COVID-19 vaccinations to stop the virus progression and transmission. In several countries, including India, the United States, and Russia, the COVID-19 vaccine has already been approved for human use. India has been able to produce two vaccines, namely Covaxin and Covishield, and launches a massive vaccination drive for people above 18 years adults. Till now, approximately 304 million subjects have been partially vaccinated and 73 million subjects are fully vaccinated. Various other COVID-19 vaccines are in Phase 3 of clinical development. Vaccines against COVID are a major tool against the progression and prevention of COVID-19.https://journals.lww.com/10.4103/injms.injms_86_21covid-19coronavirusvaccines |
| spellingShingle | Neha Chand Rajani Mathur Shridhar Dwivedi COVID-19 Vaccines: A Ray of Hope Indian Journal of Medical Specialities covid-19 coronavirus vaccines |
| title | COVID-19 Vaccines: A Ray of Hope |
| title_full | COVID-19 Vaccines: A Ray of Hope |
| title_fullStr | COVID-19 Vaccines: A Ray of Hope |
| title_full_unstemmed | COVID-19 Vaccines: A Ray of Hope |
| title_short | COVID-19 Vaccines: A Ray of Hope |
| title_sort | covid 19 vaccines a ray of hope |
| topic | covid-19 coronavirus vaccines |
| url | https://journals.lww.com/10.4103/injms.injms_86_21 |
| work_keys_str_mv | AT nehachand covid19vaccinesarayofhope AT rajanimathur covid19vaccinesarayofhope AT shridhardwivedi covid19vaccinesarayofhope |