Assessment of CPME as Sustainable Low VOC Alternative to Hexane: Optimization of Extraction Efficiency and Bioactive Compound Yield from Fenugreek Seed Oil Using Computational and Experimental Methods
This study investigates the performance of cyclopentyl methyl ether (CPME) in the extraction of fenugreek seed oil, aiming to replace the conventionally used hexane. The efficiency of this alternative solvent was evaluated first through in silico methods (based on Hansen Solubility Parameters (HSPs)...
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2024-12-01
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| Online Access: | https://www.mdpi.com/2304-8158/13/23/3899 |
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| author | Ameni Ben Abdennebi Emna Chaabani Mariem Ben Jemaa Majdi Hammami Saber Khammassi Salma Nait Mohamed Wissem Aidi Wannes Ibtissem Hamrouni Sellami Anne-Sylvie Fabiano Tixier Iness Bettaieb Rebey |
| author_facet | Ameni Ben Abdennebi Emna Chaabani Mariem Ben Jemaa Majdi Hammami Saber Khammassi Salma Nait Mohamed Wissem Aidi Wannes Ibtissem Hamrouni Sellami Anne-Sylvie Fabiano Tixier Iness Bettaieb Rebey |
| author_sort | Ameni Ben Abdennebi |
| collection | DOAJ |
| description | This study investigates the performance of cyclopentyl methyl ether (CPME) in the extraction of fenugreek seed oil, aiming to replace the conventionally used hexane. The efficiency of this alternative solvent was evaluated first through in silico methods (based on Hansen Solubility Parameters (HSPs) and Conductor-like Screening Model for Real Solvent (COSMO-RS) simulations), followed by experimental studies. Solubility computational predictions analysis revealed that CPME exhibits superior solvation power compared to hexane. Experimentally, CPME demonstrated a significantly higher oil yield (7.23%) compared to hexane (4.25%) and a better retention of beneficial unsaturated fatty acids than hexane. Additionally, the physicochemical properties of oils extracted with CPME showed enhanced oxidative stability, sterol, tocopherol, and phenolic contents, leading to superior antioxidant and antibacterial activities. Importantly, CPME’s low volatile organic compound (VOC) emissions further establish it as a more sustainable and environmentally friendly alternative to hexane, aligning with contemporary goals of reducing harmful emissions in extraction processes. Thus, this paper highlights the functional advantages of CPME, focusing on its efficiency, selectivity, and enhanced retention of bioactive compounds, positioning it as a superior extraction solvent for fenugreek seed oil compared to hexane. |
| format | Article |
| id | doaj-art-b5c26d376b1c4875bccbcd7ee7ae6162 |
| institution | Kabale University |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-b5c26d376b1c4875bccbcd7ee7ae61622024-12-13T16:26:57ZengMDPI AGFoods2304-81582024-12-011323389910.3390/foods13233899Assessment of CPME as Sustainable Low VOC Alternative to Hexane: Optimization of Extraction Efficiency and Bioactive Compound Yield from Fenugreek Seed Oil Using Computational and Experimental MethodsAmeni Ben Abdennebi0Emna Chaabani1Mariem Ben Jemaa2Majdi Hammami3Saber Khammassi4Salma Nait Mohamed5Wissem Aidi Wannes6Ibtissem Hamrouni Sellami7Anne-Sylvie Fabiano Tixier8Iness Bettaieb Rebey9Laboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Olive Biotechnology, Borj Cedria Biotechnology Center, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, BP 901, Hammam-Lif 2050, TunisiaAvignon Université, INRAE, UMR SQPOV, F-84000 Avignon, FranceLaboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, BP 901, Hammam-Lif 2050, TunisiaThis study investigates the performance of cyclopentyl methyl ether (CPME) in the extraction of fenugreek seed oil, aiming to replace the conventionally used hexane. The efficiency of this alternative solvent was evaluated first through in silico methods (based on Hansen Solubility Parameters (HSPs) and Conductor-like Screening Model for Real Solvent (COSMO-RS) simulations), followed by experimental studies. Solubility computational predictions analysis revealed that CPME exhibits superior solvation power compared to hexane. Experimentally, CPME demonstrated a significantly higher oil yield (7.23%) compared to hexane (4.25%) and a better retention of beneficial unsaturated fatty acids than hexane. Additionally, the physicochemical properties of oils extracted with CPME showed enhanced oxidative stability, sterol, tocopherol, and phenolic contents, leading to superior antioxidant and antibacterial activities. Importantly, CPME’s low volatile organic compound (VOC) emissions further establish it as a more sustainable and environmentally friendly alternative to hexane, aligning with contemporary goals of reducing harmful emissions in extraction processes. Thus, this paper highlights the functional advantages of CPME, focusing on its efficiency, selectivity, and enhanced retention of bioactive compounds, positioning it as a superior extraction solvent for fenugreek seed oil compared to hexane.https://www.mdpi.com/2304-8158/13/23/3899fenugreekgreen solventoilsfatty acidssterolstocopherols |
| spellingShingle | Ameni Ben Abdennebi Emna Chaabani Mariem Ben Jemaa Majdi Hammami Saber Khammassi Salma Nait Mohamed Wissem Aidi Wannes Ibtissem Hamrouni Sellami Anne-Sylvie Fabiano Tixier Iness Bettaieb Rebey Assessment of CPME as Sustainable Low VOC Alternative to Hexane: Optimization of Extraction Efficiency and Bioactive Compound Yield from Fenugreek Seed Oil Using Computational and Experimental Methods Foods fenugreek green solvent oils fatty acids sterols tocopherols |
| title | Assessment of CPME as Sustainable Low VOC Alternative to Hexane: Optimization of Extraction Efficiency and Bioactive Compound Yield from Fenugreek Seed Oil Using Computational and Experimental Methods |
| title_full | Assessment of CPME as Sustainable Low VOC Alternative to Hexane: Optimization of Extraction Efficiency and Bioactive Compound Yield from Fenugreek Seed Oil Using Computational and Experimental Methods |
| title_fullStr | Assessment of CPME as Sustainable Low VOC Alternative to Hexane: Optimization of Extraction Efficiency and Bioactive Compound Yield from Fenugreek Seed Oil Using Computational and Experimental Methods |
| title_full_unstemmed | Assessment of CPME as Sustainable Low VOC Alternative to Hexane: Optimization of Extraction Efficiency and Bioactive Compound Yield from Fenugreek Seed Oil Using Computational and Experimental Methods |
| title_short | Assessment of CPME as Sustainable Low VOC Alternative to Hexane: Optimization of Extraction Efficiency and Bioactive Compound Yield from Fenugreek Seed Oil Using Computational and Experimental Methods |
| title_sort | assessment of cpme as sustainable low voc alternative to hexane optimization of extraction efficiency and bioactive compound yield from fenugreek seed oil using computational and experimental methods |
| topic | fenugreek green solvent oils fatty acids sterols tocopherols |
| url | https://www.mdpi.com/2304-8158/13/23/3899 |
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