Circadian clocks and periodic anticipated fasting prevent fasting-associated hepatic steatosis in calorie restriction

Circadian clocks and periodic anticipated fasting prevent fasting-associated hepatic steatosis in calorie restriction

Summary: Calorie restriction (CR) improves health and longevity. CR induces a periodic fasting cycle in mammals; our study compares CR with unanticipated fasting (F), when the food is unexpectedly withheld. F induces hepatic steatosis, whereas CR reduces it; surprisingly, the difference is not due t...

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Main Authors: Oghogho P. Ebeigbe, Volha Mezhnina, Artem Astafev, Nikkhil Velingkaar, Jillian Kodger, Allan Poe, Jonathan Fritz, Kadaia Z. Williams, Evelina Trokhimenko, Josefa-Marie B. Rom, Yana Sandlers, Roman V. Kondratov
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500912X
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