LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions

LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions

Abstract T‐cell receptor (TCR) ligation‐mediated protein phosphorylation regulates the activation, cellular responses, and fates of T cells. Here, we used time‐resolved high‐resolution phosphoproteomics to identify, quantify, and characterize the phosphorylation dynamics of thousands of phosphorylat...

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Bibliographic Details
Main Authors: Marie Locard‐Paulet, Guillaume Voisinne, Carine Froment, Marisa Goncalves Menoita, Youcef Ounoughene, Laura Girard, Claude Gregoire, Daiki Mori, Manuel Martinez, Hervé Luche, Jerôme Garin, Marie Malissen, Odile Burlet‐Schiltz, Bernard Malissen, Anne Gonzalez de Peredo, Romain Roncagalli
Format: Article
Language:English
Published: Springer Nature 2020-07-01
Series:Molecular Systems Biology
Subjects:
dynamic biological processes
ITSN2
LymphoAtlas
phosphoproteomics
TCR signaling network
Online Access:https://doi.org/10.15252/msb.20209524
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