A multi-region single nucleus transcriptomic atlas of Parkinson’s disease
Abstract Parkinson’s Disease (PD) is a debilitating neurodegenerative disorder, characterized by motor and cognitive impairments, that affects >1% of the population over the age of 60. The pathogenesis of PD is complex and remains largely unknown. Due to the cellular heterogeneity of the human br...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-024-04117-y |
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| author | Prashant N. M. John F. Fullard Tereza Clarence Deepika Mathur Clara Casey Evelyn Hennigan Marcela Alvia Joana Krause-Massaguer Ayled Barreda David A. Davis Regina T. Vontell Susanna P. Garamszegi Jeffery M. Vance Lorelle Sang Michael Chatigny David Vismer Barry Landin David Burstein Donghoon Lee Georgios Voloudakis Sabina Berretta Vahram Haroutunian William K. Scott Jaroslav Bendl Panos Roussos |
| author_facet | Prashant N. M. John F. Fullard Tereza Clarence Deepika Mathur Clara Casey Evelyn Hennigan Marcela Alvia Joana Krause-Massaguer Ayled Barreda David A. Davis Regina T. Vontell Susanna P. Garamszegi Jeffery M. Vance Lorelle Sang Michael Chatigny David Vismer Barry Landin David Burstein Donghoon Lee Georgios Voloudakis Sabina Berretta Vahram Haroutunian William K. Scott Jaroslav Bendl Panos Roussos |
| author_sort | Prashant N. M. |
| collection | DOAJ |
| description | Abstract Parkinson’s Disease (PD) is a debilitating neurodegenerative disorder, characterized by motor and cognitive impairments, that affects >1% of the population over the age of 60. The pathogenesis of PD is complex and remains largely unknown. Due to the cellular heterogeneity of the human brain and changes in cell type composition with disease progression, this complexity cannot be fully captured with bulk tissue studies. To address this, we generated single-nucleus RNA sequencing and whole-genome sequencing data from 100 postmortem cases and controls, carefully selected to represent the entire spectrum of PD neuropathological severity and diverse clinical symptoms. The single nucleus data were generated from five brain regions, capturing the subcortical and cortical spread of PD pathology. Rigorous preprocessing and quality control were applied to ensure data reliability. Committed to collaborative research and open science, this dataset is available on the AMP PD Knowledge Platform, offering researchers a valuable tool to explore the molecular bases of PD and accelerate advances in understanding and treating the disease. |
| format | Article |
| id | doaj-art-b5a4b7a8fd6b4893a7ad2b40b848ed05 |
| institution | Kabale University |
| issn | 2052-4463 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj-art-b5a4b7a8fd6b4893a7ad2b40b848ed052024-11-24T12:10:23ZengNature PortfolioScientific Data2052-44632024-11-011111910.1038/s41597-024-04117-yA multi-region single nucleus transcriptomic atlas of Parkinson’s diseasePrashant N. M.0John F. Fullard1Tereza Clarence2Deepika Mathur3Clara Casey4Evelyn Hennigan5Marcela Alvia6Joana Krause-Massaguer7Ayled Barreda8David A. Davis9Regina T. Vontell10Susanna P. Garamszegi11Jeffery M. Vance12Lorelle Sang13Michael Chatigny14David Vismer15Barry Landin16David Burstein17Donghoon Lee18Georgios Voloudakis19Sabina Berretta20Vahram Haroutunian21William K. Scott22Jaroslav Bendl23Panos Roussos24Center for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiBrain Endowment Bank, Department of Neurology, University of Miami Miller School of MedicineBrain Endowment Bank, Department of Neurology, University of Miami Miller School of MedicineBrain Endowment Bank, Department of Neurology, University of Miami Miller School of MedicineBrain Endowment Bank, Department of Neurology, University of Miami Miller School of MedicineJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of MedicineMcLean HospitalMcLean HospitalTechnome LLCTechnome LLCCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiMcLean HospitalFriedman Brain Institute, Icahn School of Medicine at Mount SinaiBrain Endowment Bank, Department of Neurology, University of Miami Miller School of MedicineCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiCenter for Disease Neurogenomics, Icahn School of Medicine at Mount SinaiAbstract Parkinson’s Disease (PD) is a debilitating neurodegenerative disorder, characterized by motor and cognitive impairments, that affects >1% of the population over the age of 60. The pathogenesis of PD is complex and remains largely unknown. Due to the cellular heterogeneity of the human brain and changes in cell type composition with disease progression, this complexity cannot be fully captured with bulk tissue studies. To address this, we generated single-nucleus RNA sequencing and whole-genome sequencing data from 100 postmortem cases and controls, carefully selected to represent the entire spectrum of PD neuropathological severity and diverse clinical symptoms. The single nucleus data were generated from five brain regions, capturing the subcortical and cortical spread of PD pathology. Rigorous preprocessing and quality control were applied to ensure data reliability. Committed to collaborative research and open science, this dataset is available on the AMP PD Knowledge Platform, offering researchers a valuable tool to explore the molecular bases of PD and accelerate advances in understanding and treating the disease.https://doi.org/10.1038/s41597-024-04117-y |
| spellingShingle | Prashant N. M. John F. Fullard Tereza Clarence Deepika Mathur Clara Casey Evelyn Hennigan Marcela Alvia Joana Krause-Massaguer Ayled Barreda David A. Davis Regina T. Vontell Susanna P. Garamszegi Jeffery M. Vance Lorelle Sang Michael Chatigny David Vismer Barry Landin David Burstein Donghoon Lee Georgios Voloudakis Sabina Berretta Vahram Haroutunian William K. Scott Jaroslav Bendl Panos Roussos A multi-region single nucleus transcriptomic atlas of Parkinson’s disease Scientific Data |
| title | A multi-region single nucleus transcriptomic atlas of Parkinson’s disease |
| title_full | A multi-region single nucleus transcriptomic atlas of Parkinson’s disease |
| title_fullStr | A multi-region single nucleus transcriptomic atlas of Parkinson’s disease |
| title_full_unstemmed | A multi-region single nucleus transcriptomic atlas of Parkinson’s disease |
| title_short | A multi-region single nucleus transcriptomic atlas of Parkinson’s disease |
| title_sort | multi region single nucleus transcriptomic atlas of parkinson s disease |
| url | https://doi.org/10.1038/s41597-024-04117-y |
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