HSP70-Mediated Autophagy-Apoptosis-Inflammation Network and Neuroprotection Induced by Heat Acclimatization
Global warming has intensified the health risks associated with heat stress, such as heatstroke and dehydration, underscoring the importance of understanding heat acclimatization (HA). HA involves physiological, psychological, and structural adaptations to prolonged high temperatures, improving heat...
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MDPI AG
2025-06-01
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| Series: | Biology |
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| author | Yuchen Su Xinyan Zheng |
| author_facet | Yuchen Su Xinyan Zheng |
| author_sort | Yuchen Su |
| collection | DOAJ |
| description | Global warming has intensified the health risks associated with heat stress, such as heatstroke and dehydration, underscoring the importance of understanding heat acclimatization (HA). HA involves physiological, psychological, and structural adaptations to prolonged high temperatures, improving heat tolerance and reducing heat-related harm. A key player in this process is HSP70, a conserved protein essential for maintaining cellular balance, regulating cell death, and controlling waste removal. While HA mechanisms like temperature regulation and metabolic changes are well studied, the relationship between HSP70 and brain self-repair processes remains unclear. This study uncovers how HSP70, and these processes work together to aid heat adaptation, reveals how environmental stress drives inherited resilience through genetic adjustments, and offers insights for designing targeted health strategies to protect vulnerable populations, connecting lab discoveries to global health needs. |
| format | Article |
| id | doaj-art-b59b2308ddee4ffb8108d1890ad1b26f |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-b59b2308ddee4ffb8108d1890ad1b26f2025-08-20T03:58:25ZengMDPI AGBiology2079-77372025-06-0114777410.3390/biology14070774HSP70-Mediated Autophagy-Apoptosis-Inflammation Network and Neuroprotection Induced by Heat AcclimatizationYuchen Su0Xinyan Zheng1School of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Yangpu, Shanghai 200438, ChinaSchool of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Yangpu, Shanghai 200438, ChinaGlobal warming has intensified the health risks associated with heat stress, such as heatstroke and dehydration, underscoring the importance of understanding heat acclimatization (HA). HA involves physiological, psychological, and structural adaptations to prolonged high temperatures, improving heat tolerance and reducing heat-related harm. A key player in this process is HSP70, a conserved protein essential for maintaining cellular balance, regulating cell death, and controlling waste removal. While HA mechanisms like temperature regulation and metabolic changes are well studied, the relationship between HSP70 and brain self-repair processes remains unclear. This study uncovers how HSP70, and these processes work together to aid heat adaptation, reveals how environmental stress drives inherited resilience through genetic adjustments, and offers insights for designing targeted health strategies to protect vulnerable populations, connecting lab discoveries to global health needs.https://www.mdpi.com/2079-7737/14/7/774HSP70heat acclimatizationautophagyheat stressneuroprotectionmolecular chaperones |
| spellingShingle | Yuchen Su Xinyan Zheng HSP70-Mediated Autophagy-Apoptosis-Inflammation Network and Neuroprotection Induced by Heat Acclimatization Biology HSP70 heat acclimatization autophagy heat stress neuroprotection molecular chaperones |
| title | HSP70-Mediated Autophagy-Apoptosis-Inflammation Network and Neuroprotection Induced by Heat Acclimatization |
| title_full | HSP70-Mediated Autophagy-Apoptosis-Inflammation Network and Neuroprotection Induced by Heat Acclimatization |
| title_fullStr | HSP70-Mediated Autophagy-Apoptosis-Inflammation Network and Neuroprotection Induced by Heat Acclimatization |
| title_full_unstemmed | HSP70-Mediated Autophagy-Apoptosis-Inflammation Network and Neuroprotection Induced by Heat Acclimatization |
| title_short | HSP70-Mediated Autophagy-Apoptosis-Inflammation Network and Neuroprotection Induced by Heat Acclimatization |
| title_sort | hsp70 mediated autophagy apoptosis inflammation network and neuroprotection induced by heat acclimatization |
| topic | HSP70 heat acclimatization autophagy heat stress neuroprotection molecular chaperones |
| url | https://www.mdpi.com/2079-7737/14/7/774 |
| work_keys_str_mv | AT yuchensu hsp70mediatedautophagyapoptosisinflammationnetworkandneuroprotectioninducedbyheatacclimatization AT xinyanzheng hsp70mediatedautophagyapoptosisinflammationnetworkandneuroprotectioninducedbyheatacclimatization |