Challenges in the diagmosis of cervical pathologies
This review deals with the current state of affairs in the diagnosis of cervical squamous intraepithelial lesions. Transformation of classifications of cervical pathologies is considered. The role of cytological (liquid-based and conventional cytology), molecular biological (Digene Hybrid Capture te...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2024-01-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/5436 |
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| author | D. Y. Chernov O. A. Tikhonovskaya S. V. Logvinov I. A. Petrov Y. S. Yuriev A. A. Zhdankina A. V. Gerasimov I. V. Zingalyuk G. A. Mikheenko |
| author_facet | D. Y. Chernov O. A. Tikhonovskaya S. V. Logvinov I. A. Petrov Y. S. Yuriev A. A. Zhdankina A. V. Gerasimov I. V. Zingalyuk G. A. Mikheenko |
| author_sort | D. Y. Chernov |
| collection | DOAJ |
| description | This review deals with the current state of affairs in the diagnosis of cervical squamous intraepithelial lesions. Transformation of classifications of cervical pathologies is considered. The role of cytological (liquid-based and conventional cytology), molecular biological (Digene Hybrid Capture test), immunohistochemical (p16INK4α, Ki-67), and histologic methods in the diagnosis of cervical lesions is discussed. Particular attention is paid to the diagnosis of human papillomavirus infection. Performance indicators of screening programs based on primary determination of human papillomavirus (HPV) DNA in comparison with common cytological methods are presented. Tropism of HPV to various parts of the cervix, which predisposes to the formation of deep multifocal lesions, as well as the influence of the physical status of HPV on the treatment strategy and risks of relapse are considered. |
| format | Article |
| id | doaj-art-b59770a96e9d4266a51a87ad88c50b8c |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-b59770a96e9d4266a51a87ad88c50b8c2025-08-20T03:02:04ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842024-01-0122420120910.20538/1682-0363-2023-4-201-2093045Challenges in the diagmosis of cervical pathologiesD. Y. Chernov0O. A. Tikhonovskaya1S. V. Logvinov2I. A. Petrov3Y. S. Yuriev4A. A. Zhdankina5A. V. Gerasimov6I. V. Zingalyuk7G. A. Mikheenko8Siberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversityThis review deals with the current state of affairs in the diagnosis of cervical squamous intraepithelial lesions. Transformation of classifications of cervical pathologies is considered. The role of cytological (liquid-based and conventional cytology), molecular biological (Digene Hybrid Capture test), immunohistochemical (p16INK4α, Ki-67), and histologic methods in the diagnosis of cervical lesions is discussed. Particular attention is paid to the diagnosis of human papillomavirus infection. Performance indicators of screening programs based on primary determination of human papillomavirus (HPV) DNA in comparison with common cytological methods are presented. Tropism of HPV to various parts of the cervix, which predisposes to the formation of deep multifocal lesions, as well as the influence of the physical status of HPV on the treatment strategy and risks of relapse are considered.https://bulletin.ssmu.ru/jour/article/view/5436cervical squamous intraepithelial lesionscervical intraepithelial neoplasiahpvdiagnosis |
| spellingShingle | D. Y. Chernov O. A. Tikhonovskaya S. V. Logvinov I. A. Petrov Y. S. Yuriev A. A. Zhdankina A. V. Gerasimov I. V. Zingalyuk G. A. Mikheenko Challenges in the diagmosis of cervical pathologies Бюллетень сибирской медицины cervical squamous intraepithelial lesions cervical intraepithelial neoplasia hpv diagnosis |
| title | Challenges in the diagmosis of cervical pathologies |
| title_full | Challenges in the diagmosis of cervical pathologies |
| title_fullStr | Challenges in the diagmosis of cervical pathologies |
| title_full_unstemmed | Challenges in the diagmosis of cervical pathologies |
| title_short | Challenges in the diagmosis of cervical pathologies |
| title_sort | challenges in the diagmosis of cervical pathologies |
| topic | cervical squamous intraepithelial lesions cervical intraepithelial neoplasia hpv diagnosis |
| url | https://bulletin.ssmu.ru/jour/article/view/5436 |
| work_keys_str_mv | AT dychernov challengesinthediagmosisofcervicalpathologies AT oatikhonovskaya challengesinthediagmosisofcervicalpathologies AT svlogvinov challengesinthediagmosisofcervicalpathologies AT iapetrov challengesinthediagmosisofcervicalpathologies AT ysyuriev challengesinthediagmosisofcervicalpathologies AT aazhdankina challengesinthediagmosisofcervicalpathologies AT avgerasimov challengesinthediagmosisofcervicalpathologies AT ivzingalyuk challengesinthediagmosisofcervicalpathologies AT gamikheenko challengesinthediagmosisofcervicalpathologies |