Serum amino acid alterations in hyperuricemia: potential targets for renal disease prevention

Serum amino acid alterations in hyperuricemia: potential targets for renal disease prevention

Abstract Observational studies have linked uric acid (UA) levels and kidney disease to amino acid homeostasis, but the causal relationship is unclear. This study aims to determine if elevated UA affects amino acid levels and whether amino acids mediate this relationship, focusing on the causal links...

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Bibliographic Details
Main Authors: Qinglin Sheng, Yuqing Ma, Bingjie Geng, Jiahui Chen, Junfei Cheng, Su Liu, Rui Li, Xiangtong Li, Jing Wang, Hongtao Lu, Fangyuan Gao, Fu Gao
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Amino Acids
Subjects:
Uric acid
Hyperuricemia
Amino acidomics
Mendelian randomization
Mediating effect
Online Access:https://doi.org/10.1007/s00726-025-03444-7
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