The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology
IntroductionNeuroimaging studies have demonstrated that intranasal oxytocin has extensive effects on the resting state functional connectivity of social and emotional processing networks and may have therapeutic potential. However, the extent to which intranasal oxytocin modulates functional connect...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1460513/full |
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| author | Abraham Tonny Hagan Lei Xu Benjamin Klugah-Brown Jialin Li Xi Jiang Keith M. Kendrick |
| author_facet | Abraham Tonny Hagan Lei Xu Benjamin Klugah-Brown Jialin Li Xi Jiang Keith M. Kendrick |
| author_sort | Abraham Tonny Hagan |
| collection | DOAJ |
| description | IntroductionNeuroimaging studies have demonstrated that intranasal oxytocin has extensive effects on the resting state functional connectivity of social and emotional processing networks and may have therapeutic potential. However, the extent to which intranasal oxytocin modulates functional connectivity network topology remains less explored, with inconsistent findings in the existing literature. To address this gap, we conducted an exploratory data-driven study.MethodsWe recruited 142 healthy males and administered 24 IU of intranasal oxytocin or placebo in a randomized controlled double-blind design. Resting-state functional MRI data were acquired for each subject. Network-based statistical analysis and graph theoretical approaches were employed to evaluate oxytocin’s effects on whole-brain functional connectivity and graph topological measures.ResultsOur results revealed that oxytocin altered connectivity patterns within brain networks involved in sensory and motor processing, attention, memory, emotion and reward functions as well as social cognition, including the default mode, limbic, frontoparietal, cerebellar, and visual networks. Furthermore, oxytocin increased local efficiency, clustering coefficients, and small-world propensity in specific brain regions including the cerebellum, left thalamus, posterior cingulate cortex, right orbitofrontal cortex, right superior frontal gyrus, left inferior frontal gyrus, and right middle orbitofrontal cortex, while decreasing nodal path topological measures in the left and right caudate.DiscussionThese findings suggest that intranasal oxytocin may produce its functional effects through influencing the integration and segregation of information flow within small-world brain networks, particularly in regions closely associated with social cognition and motivation. |
| format | Article |
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| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-b58b0036230e42c1acd28afaea77e3a92025-01-06T06:58:57ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14605131460513The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topologyAbraham Tonny HaganLei XuBenjamin Klugah-BrownJialin LiXi JiangKeith M. KendrickIntroductionNeuroimaging studies have demonstrated that intranasal oxytocin has extensive effects on the resting state functional connectivity of social and emotional processing networks and may have therapeutic potential. However, the extent to which intranasal oxytocin modulates functional connectivity network topology remains less explored, with inconsistent findings in the existing literature. To address this gap, we conducted an exploratory data-driven study.MethodsWe recruited 142 healthy males and administered 24 IU of intranasal oxytocin or placebo in a randomized controlled double-blind design. Resting-state functional MRI data were acquired for each subject. Network-based statistical analysis and graph theoretical approaches were employed to evaluate oxytocin’s effects on whole-brain functional connectivity and graph topological measures.ResultsOur results revealed that oxytocin altered connectivity patterns within brain networks involved in sensory and motor processing, attention, memory, emotion and reward functions as well as social cognition, including the default mode, limbic, frontoparietal, cerebellar, and visual networks. Furthermore, oxytocin increased local efficiency, clustering coefficients, and small-world propensity in specific brain regions including the cerebellum, left thalamus, posterior cingulate cortex, right orbitofrontal cortex, right superior frontal gyrus, left inferior frontal gyrus, and right middle orbitofrontal cortex, while decreasing nodal path topological measures in the left and right caudate.DiscussionThese findings suggest that intranasal oxytocin may produce its functional effects through influencing the integration and segregation of information flow within small-world brain networks, particularly in regions closely associated with social cognition and motivation.https://www.frontiersin.org/articles/10.3389/fphar.2024.1460513/fulloxytocinresting state fMRIsmall-worldnessgraph theorypharmacodynamics |
| spellingShingle | Abraham Tonny Hagan Lei Xu Benjamin Klugah-Brown Jialin Li Xi Jiang Keith M. Kendrick The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology Frontiers in Pharmacology oxytocin resting state fMRI small-worldness graph theory pharmacodynamics |
| title | The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology |
| title_full | The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology |
| title_fullStr | The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology |
| title_full_unstemmed | The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology |
| title_short | The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology |
| title_sort | pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology |
| topic | oxytocin resting state fMRI small-worldness graph theory pharmacodynamics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1460513/full |
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