Recent advances in single fluorescent probes for monitoring dual organelles in two channels
Abstract Organelles are specialized areas where cells perform specific processes necessary for life and actively communicate with each other to keep the whole cell functioning. Disorders of the organelle networks are associated with multiple pathological processes. However, clearly and intuitively v...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Smart Molecules |
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| Online Access: | https://doi.org/10.1002/smo.20240040 |
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| author | Xiu‐Zhi Yang Shankun Yao Jisong Wu Jiajie Diao Weijiang He Zijian Guo Yuncong Chen |
| author_facet | Xiu‐Zhi Yang Shankun Yao Jisong Wu Jiajie Diao Weijiang He Zijian Guo Yuncong Chen |
| author_sort | Xiu‐Zhi Yang |
| collection | DOAJ |
| description | Abstract Organelles are specialized areas where cells perform specific processes necessary for life and actively communicate with each other to keep the whole cell functioning. Disorders of the organelle networks are associated with multiple pathological processes. However, clearly and intuitively visualizing the highly dynamic interactions between ultrafine organelles is challenging. Fluorescence imaging technology provides opportunities due to the distinct advantages of facile, non‐invasiveness and dynamic detection, making it particularly well‐suited for applications in uncovering the mysterious veil of organelle interactions. Regrettably, the lack of ideal fluorescence agents has always been an obstacle in imaging the intricate behaviors of organelles. In this review, we provide a systematic discussion on the existing dual‐color and dual‐targetable molecular sensors used in monitoring organelle interactions, with a specific focus on their targeting strategies, imaging mechanisms and biological applications. Additionally, the current limitations and future development directions of dual‐targetable probes and dual‐emissives are briefly discussed. This review aims to provide guidance for researchers to develop more improved probes for studying organelle interactions in the biomedical field. |
| format | Article |
| id | doaj-art-b57b8ebdf62b4d3a80cedc2a4cd782d4 |
| institution | Kabale University |
| issn | 2751-4587 2751-4595 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Smart Molecules |
| spelling | doaj-art-b57b8ebdf62b4d3a80cedc2a4cd782d42024-12-20T12:25:07ZengWileySmart Molecules2751-45872751-45952024-12-0124n/an/a10.1002/smo.20240040Recent advances in single fluorescent probes for monitoring dual organelles in two channelsXiu‐Zhi Yang0Shankun Yao1Jisong Wu2Jiajie Diao3Weijiang He4Zijian Guo5Yuncong Chen6State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing ChinaState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing ChinaState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing ChinaDepartment of Cancer Biology University of Cincinnati College of Medicine Cincinnati Ohio USAState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing ChinaState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing ChinaState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing ChinaAbstract Organelles are specialized areas where cells perform specific processes necessary for life and actively communicate with each other to keep the whole cell functioning. Disorders of the organelle networks are associated with multiple pathological processes. However, clearly and intuitively visualizing the highly dynamic interactions between ultrafine organelles is challenging. Fluorescence imaging technology provides opportunities due to the distinct advantages of facile, non‐invasiveness and dynamic detection, making it particularly well‐suited for applications in uncovering the mysterious veil of organelle interactions. Regrettably, the lack of ideal fluorescence agents has always been an obstacle in imaging the intricate behaviors of organelles. In this review, we provide a systematic discussion on the existing dual‐color and dual‐targetable molecular sensors used in monitoring organelle interactions, with a specific focus on their targeting strategies, imaging mechanisms and biological applications. Additionally, the current limitations and future development directions of dual‐targetable probes and dual‐emissives are briefly discussed. This review aims to provide guidance for researchers to develop more improved probes for studying organelle interactions in the biomedical field.https://doi.org/10.1002/smo.20240040bioimagingdual‐colordual‐targetedfluorescent probesorganelle interaction |
| spellingShingle | Xiu‐Zhi Yang Shankun Yao Jisong Wu Jiajie Diao Weijiang He Zijian Guo Yuncong Chen Recent advances in single fluorescent probes for monitoring dual organelles in two channels Smart Molecules bioimaging dual‐color dual‐targeted fluorescent probes organelle interaction |
| title | Recent advances in single fluorescent probes for monitoring dual organelles in two channels |
| title_full | Recent advances in single fluorescent probes for monitoring dual organelles in two channels |
| title_fullStr | Recent advances in single fluorescent probes for monitoring dual organelles in two channels |
| title_full_unstemmed | Recent advances in single fluorescent probes for monitoring dual organelles in two channels |
| title_short | Recent advances in single fluorescent probes for monitoring dual organelles in two channels |
| title_sort | recent advances in single fluorescent probes for monitoring dual organelles in two channels |
| topic | bioimaging dual‐color dual‐targeted fluorescent probes organelle interaction |
| url | https://doi.org/10.1002/smo.20240040 |
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