RGS1 and CREB5 are direct and common transcriptional targets of ZNF384‐fusion proteins

RGS1 and CREB5 are direct and common transcriptional targets of ZNF384‐fusion proteins

Abstract Background ZNF384‐fusion (Z‐fusion) genes were recently identified in B‐cell acute lymphoblastic leukemia (B‐ALL) and are frequent in Japanese adult patients. The frequency is about 20% in those with Philadelphia chromosome‐negative B‐ALL. ZNF384 is a transcription factor and Z‐fusion prote...

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Main Authors: Chiharu Yamada, Kentaro Okada, Koya Odaira, Mahiru Tokoro, Eisuke Iwamoto, Masashi Sanada, Mina Noura, Syuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa
Format: Article
Language:English
Published: Wiley 2024-07-01
Series:Cancer Medicine
Subjects:
acute lymphoblastic leukemia
fusion gene
RNA‐seq
transcriptional target
ZNF384
Online Access:https://doi.org/10.1002/cam4.7471
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