Hematological ratios and cytokine profiles in heterozygous beta-thalassemia
Introduction: β-Thalassemia is defined by a reduced or complete absence of β-globin chain synthesis in hemoglobin, leading to hemolytic anemia. Heterozygous β-thalassemia, also known as β-thalassemia trait (hBTh), the mildest form of this anemia, typically does not cause symptoms in carriers. Howeve...
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Elsevier
2025-07-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137925001130 |
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| author | Ana Carolina Marques Ciceri Laura Eduarda de Oliveira Ana Luísa Richter José Antonio Mainardi de Carvalho Maylla Rodrigues Lucena Guilherme Wataru Gomes Maria Stella Figueiredo Magnun Nueldo Nunes dos Santos Vera Lúcia Nascimento Blaia-D'Avila Rodolfo Delfini Cançado Elvira Maria Guerra-Shinohara Clóvis Paniz |
| author_facet | Ana Carolina Marques Ciceri Laura Eduarda de Oliveira Ana Luísa Richter José Antonio Mainardi de Carvalho Maylla Rodrigues Lucena Guilherme Wataru Gomes Maria Stella Figueiredo Magnun Nueldo Nunes dos Santos Vera Lúcia Nascimento Blaia-D'Avila Rodolfo Delfini Cançado Elvira Maria Guerra-Shinohara Clóvis Paniz |
| author_sort | Ana Carolina Marques Ciceri |
| collection | DOAJ |
| description | Introduction: β-Thalassemia is defined by a reduced or complete absence of β-globin chain synthesis in hemoglobin, leading to hemolytic anemia. Heterozygous β-thalassemia, also known as β-thalassemia trait (hBTh), the mildest form of this anemia, typically does not cause symptoms in carriers. However, it may lead to changes in the immune system, including an increase in total leukocyte, neutrophil, and lymphocyte counts. Objective: This study aimed to evaluate various immune and inflammation markers, including neutrophil/lymphocyte, derived neutrophil/lymphocyte, lymphocyte/monocyte, platelet/lymphocyte, neutrophil/platelet ratios, systemic immune-inflammation index, systemic inflammation response index, neutrophil/natural killer cell ratio (NNKR), and inflammatory cytokines in β-thalassemia trait carriers. Method: A retrospective observational study was conducted, including 50 β-thalassemia trait individuals and 100 healthy controls. Results: Leukocyte, neutrophil and reticulocyte counts, and interleukin 6 levels were higher in carriers compared to controls. Notably, the β-thalassemia trait group had increased neutrophil/platelet, neutrophil/lymphocyte and derived neutrophil/lymphocyte ratios, and the systemic immune-inflammation and systemic inflammation response indexes were higher compared to the controls. Conclusions: β-thalassemia trait shows a more pronounced inflammatory profile as indicated by hematological ratios. These ratios, therefore are potentially cost-effective and easily applicable markers for monitoring patients with the β-thalassemia trait. |
| format | Article |
| id | doaj-art-b553471f6f5a4446be9ec16eee857a51 |
| institution | Kabale University |
| issn | 2531-1379 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-b553471f6f5a4446be9ec16eee857a512025-08-20T03:59:37ZengElsevierHematology, Transfusion and Cell Therapy2531-13792025-07-0147310384510.1016/j.htct.2025.103845Hematological ratios and cytokine profiles in heterozygous beta-thalassemiaAna Carolina Marques Ciceri0Laura Eduarda de Oliveira1Ana Luísa Richter2José Antonio Mainardi de Carvalho3Maylla Rodrigues Lucena4Guilherme Wataru Gomes5Maria Stella Figueiredo6Magnun Nueldo Nunes dos Santos7Vera Lúcia Nascimento Blaia-D'Avila8Rodolfo Delfini Cançado9Elvira Maria Guerra-Shinohara10Clóvis Paniz11Universidade Federal de Santa Maria, Departamento de Análises Clínicas e Toxicológicas, Laboratório de Pesquisas em Análises Clínicas Aplicadas - LAPACA, Santa Maria, RS, BrazilUniversidade Federal de Santa Maria, Departamento de Análises Clínicas e Toxicológicas, Laboratório de Pesquisas em Análises Clínicas Aplicadas - LAPACA, Santa Maria, RS, BrazilUniversidade Federal de Santa Maria, Departamento de Análises Clínicas e Toxicológicas, Laboratório de Pesquisas em Análises Clínicas Aplicadas - LAPACA, Santa Maria, RS, BrazilUniversidade Federal de Santa Maria, Departamento de Análises Clínicas e Toxicológicas, Laboratório de Pesquisas em Análises Clínicas Aplicadas - LAPACA, Santa Maria, RS, BrazilUniversidade Ceuma - Campus Imperatriz, Imperatriz, MA, Brazil; Universidade Federal de São Paulo, Disciplina de Hematologia e Hemoterapia, São Paulo, SP, BrazilUniversidade Federal Fluminense, Departamento de Patologia, Niterói, RJ, BrazilUniversidade Federal de São Paulo, Disciplina de Hematologia e Hemoterapia, São Paulo, SP, BrazilUniversidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Patologia Clínica, São Paulo, SP, BrazilPontifícia Universidade Católica de São Paulo, Faculdade de Medicina e Ciências da Saúde, Divisão de Hematologia, Sorocaba, SP, BrazilFaculdade de Ciências Médicas da Santa Casa de São Paulo, Departmento de Hematologia e Oncologia, São Paulo, SP, BrazilUniversidade Federal de São Paulo, Disciplina de Hematologia e Hemoterapia, São Paulo, SP, BrazilUniversidade Federal de Santa Maria, Departamento de Análises Clínicas e Toxicológicas, Laboratório de Pesquisas em Análises Clínicas Aplicadas - LAPACA, Santa Maria, RS, Brazil; Corresponding author. Clóvis Paniz; Applied Clinical Analysis Research Laboratory (LAPACA), Department of Clinical and Toxicological Analyses, Federal University of Santa Maria, Av. Roraima, no. 1000, Building 26 G, Lab 01, 97105-900, Santa Maria, Rio Grande do Sul, Brazil.Introduction: β-Thalassemia is defined by a reduced or complete absence of β-globin chain synthesis in hemoglobin, leading to hemolytic anemia. Heterozygous β-thalassemia, also known as β-thalassemia trait (hBTh), the mildest form of this anemia, typically does not cause symptoms in carriers. However, it may lead to changes in the immune system, including an increase in total leukocyte, neutrophil, and lymphocyte counts. Objective: This study aimed to evaluate various immune and inflammation markers, including neutrophil/lymphocyte, derived neutrophil/lymphocyte, lymphocyte/monocyte, platelet/lymphocyte, neutrophil/platelet ratios, systemic immune-inflammation index, systemic inflammation response index, neutrophil/natural killer cell ratio (NNKR), and inflammatory cytokines in β-thalassemia trait carriers. Method: A retrospective observational study was conducted, including 50 β-thalassemia trait individuals and 100 healthy controls. Results: Leukocyte, neutrophil and reticulocyte counts, and interleukin 6 levels were higher in carriers compared to controls. Notably, the β-thalassemia trait group had increased neutrophil/platelet, neutrophil/lymphocyte and derived neutrophil/lymphocyte ratios, and the systemic immune-inflammation and systemic inflammation response indexes were higher compared to the controls. Conclusions: β-thalassemia trait shows a more pronounced inflammatory profile as indicated by hematological ratios. These ratios, therefore are potentially cost-effective and easily applicable markers for monitoring patients with the β-thalassemia trait.http://www.sciencedirect.com/science/article/pii/S2531137925001130Β-thalassemiaHeterozygotic thalassemiaHematologic ratiosInflammationHemolytic anemia |
| spellingShingle | Ana Carolina Marques Ciceri Laura Eduarda de Oliveira Ana Luísa Richter José Antonio Mainardi de Carvalho Maylla Rodrigues Lucena Guilherme Wataru Gomes Maria Stella Figueiredo Magnun Nueldo Nunes dos Santos Vera Lúcia Nascimento Blaia-D'Avila Rodolfo Delfini Cançado Elvira Maria Guerra-Shinohara Clóvis Paniz Hematological ratios and cytokine profiles in heterozygous beta-thalassemia Hematology, Transfusion and Cell Therapy Β-thalassemia Heterozygotic thalassemia Hematologic ratios Inflammation Hemolytic anemia |
| title | Hematological ratios and cytokine profiles in heterozygous beta-thalassemia |
| title_full | Hematological ratios and cytokine profiles in heterozygous beta-thalassemia |
| title_fullStr | Hematological ratios and cytokine profiles in heterozygous beta-thalassemia |
| title_full_unstemmed | Hematological ratios and cytokine profiles in heterozygous beta-thalassemia |
| title_short | Hematological ratios and cytokine profiles in heterozygous beta-thalassemia |
| title_sort | hematological ratios and cytokine profiles in heterozygous beta thalassemia |
| topic | Β-thalassemia Heterozygotic thalassemia Hematologic ratios Inflammation Hemolytic anemia |
| url | http://www.sciencedirect.com/science/article/pii/S2531137925001130 |
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