The role of LKB1 in prostate cancer: implications for tumor progression and therapy

The role of LKB1 in prostate cancer: implications for tumor progression and therapy

Liver kinase B1 (LKB1/STK11) is a key tumor suppressor that regulates cellular metabolism, epigenetic states, and multiple signaling pathways in prostate cancer (PCa). Recent studies reveal that both genetic and non-genetic LKB1 loss drives metabolic reprogramming, lineage plasticity, and treatment...

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Bibliographic Details
Main Authors: Yuwei Liang, Hongliang Cao, Zhijun Tang, Shuxin Li, Gang Yang, Shuai Dong, Hao Du, Jinguo Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
LKB1
prostate cancer
signaling pathway regulation
epigenetic regulation
precision therapeutic targets
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1629844/full
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