Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis
Abstract Liposomes, spherical vesicles made of phospholipids and cholesterol, have captivated researchers for their encapsulation abilities, biocompatibility, and versatility. This review delves into the core aspects and benefits of liposomal technology for enhancing transdermal drug delivery in tre...
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BMC
2025-08-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03660-z |
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| author | Anmol Choudhury Apoorv Kirti Sudakshya S. Lenka Shaikh Sheeran Naser Adrija Sinha Shalini Kumari Nagendra Kumar Kaushik Aishee Ghosh Suresh K. Verma |
| author_facet | Anmol Choudhury Apoorv Kirti Sudakshya S. Lenka Shaikh Sheeran Naser Adrija Sinha Shalini Kumari Nagendra Kumar Kaushik Aishee Ghosh Suresh K. Verma |
| author_sort | Anmol Choudhury |
| collection | DOAJ |
| description | Abstract Liposomes, spherical vesicles made of phospholipids and cholesterol, have captivated researchers for their encapsulation abilities, biocompatibility, and versatility. This review delves into the core aspects and benefits of liposomal technology for enhancing transdermal drug delivery in treating skin dermatosis. It offers an extensive overview of liposomes, emphasizing various preparation methods, classification, and encapsulation techniques. The encapsulation of therapeutic compounds by liposomes boosts their utility as a stable and efficient drug delivery vehicle. Transdermal delivery presents a non-invasive alternative to oral and parenteral routes, allowing for controlled and sustained release of drugs while bypassing hepatic first-pass metabolism and minimizing systemic side effects. However, the stratum corneum acts as a formidable barrier to drug permeation. Liposomes, owing to their lipid bilayer structure that mimics skin composition, enhance drug solubility and partitioning, facilitate deeper skin penetration, and improve therapeutic efficacy, making them ideal carriers for transdermal applications. Transdermal delivery, favoured for its active and passive approaches and advantages over topical delivery, has been extensively studied and employed for therapeutics. Liposomes as delivery vehicles have significantly improved drug delivery efficiency and stability in transdermal applications. This review comprehensively examines the utility and mechanistic applications of liposomes. It also addresses the limitations and challenges in liposomal formulation that must be overcome for successful clinical trials. Graphical abstract |
| format | Article |
| id | doaj-art-b51ef4b7b628444a8b643f495fa91213 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-b51ef4b7b628444a8b643f495fa912132025-08-24T11:48:49ZengBMCJournal of Nanobiotechnology1477-31552025-08-0123114210.1186/s12951-025-03660-zStrategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosisAnmol Choudhury0Apoorv Kirti1Sudakshya S. Lenka2Shaikh Sheeran Naser3Adrija Sinha4Shalini Kumari5Nagendra Kumar Kaushik6Aishee Ghosh7Suresh K. Verma8KIIT School of Biotechnology, KIIT UniversityKIIT School of Biotechnology, KIIT UniversityKIIT School of Biotechnology, KIIT UniversityKIIT School of Biotechnology, KIIT UniversityKIIT School of Biotechnology, KIIT UniversityMarkham College of Commerce, Vinoba Bhave UniversityPlasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon UniversityDepartment of Physics and Astronomy, Uppsala UniversityKIIT School of Biotechnology, KIIT UniversityAbstract Liposomes, spherical vesicles made of phospholipids and cholesterol, have captivated researchers for their encapsulation abilities, biocompatibility, and versatility. This review delves into the core aspects and benefits of liposomal technology for enhancing transdermal drug delivery in treating skin dermatosis. It offers an extensive overview of liposomes, emphasizing various preparation methods, classification, and encapsulation techniques. The encapsulation of therapeutic compounds by liposomes boosts their utility as a stable and efficient drug delivery vehicle. Transdermal delivery presents a non-invasive alternative to oral and parenteral routes, allowing for controlled and sustained release of drugs while bypassing hepatic first-pass metabolism and minimizing systemic side effects. However, the stratum corneum acts as a formidable barrier to drug permeation. Liposomes, owing to their lipid bilayer structure that mimics skin composition, enhance drug solubility and partitioning, facilitate deeper skin penetration, and improve therapeutic efficacy, making them ideal carriers for transdermal applications. Transdermal delivery, favoured for its active and passive approaches and advantages over topical delivery, has been extensively studied and employed for therapeutics. Liposomes as delivery vehicles have significantly improved drug delivery efficiency and stability in transdermal applications. This review comprehensively examines the utility and mechanistic applications of liposomes. It also addresses the limitations and challenges in liposomal formulation that must be overcome for successful clinical trials. Graphical abstracthttps://doi.org/10.1186/s12951-025-03660-zLiposomeEncapsulationTransdermalDrug deliverySkin diseases |
| spellingShingle | Anmol Choudhury Apoorv Kirti Sudakshya S. Lenka Shaikh Sheeran Naser Adrija Sinha Shalini Kumari Nagendra Kumar Kaushik Aishee Ghosh Suresh K. Verma Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis Journal of Nanobiotechnology Liposome Encapsulation Transdermal Drug delivery Skin diseases |
| title | Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis |
| title_full | Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis |
| title_fullStr | Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis |
| title_full_unstemmed | Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis |
| title_short | Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis |
| title_sort | strategic advances in liposomes technology translational paradigm in transdermal delivery for skin dermatosis |
| topic | Liposome Encapsulation Transdermal Drug delivery Skin diseases |
| url | https://doi.org/10.1186/s12951-025-03660-z |
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