Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
There is accumulating evidence highlighting a close relationship between inflammation and coronary microvascular dysfunction (CMD) in various experimental and clinical settings, with major clinical implications. Chronic low-grade vascular inflammation plays important roles in the underlying mechanis...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2021-03-01
|
| Series: | European Cardiology Review |
| Online Access: | https://www.ecrjournal.com/articleindex/ecr.2020.47 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846122489712738304 |
|---|---|
| author | Shigeo Godo Jun Takahashi Satoshi Yasuda Hiroaki Shimokawa |
| author_facet | Shigeo Godo Jun Takahashi Satoshi Yasuda Hiroaki Shimokawa |
| author_sort | Shigeo Godo |
| collection | DOAJ |
| description | There is accumulating evidence highlighting a close relationship between inflammation and coronary microvascular dysfunction (CMD) in various experimental and clinical settings, with major clinical implications. Chronic low-grade vascular inflammation plays important roles in the underlying mechanisms behind CMD, especially in patients with coronary artery disease, obesity, heart failure with preserved ejection fraction and chronic inflammatory rheumatoid diseases. The central mechanisms of coronary vasomotion abnormalities comprise enhanced coronary vasoconstrictor reactivity, reduced endothelium-dependent and -independent coronary vasodilator capacity and increased coronary microvascular resistance, where inflammatory mediators and responses are substantially involved. How to modulate CMD to improve clinical outcomes of patients with the disorder and whether CMD management by targeting inflammatory responses can benefit patients remain challenging questions in need of further research. This review provides a concise overview of the current knowledge of the involvement of inflammation in the pathophysiology and molecular mechanisms of CMD from bench to bedside. |
| format | Article |
| id | doaj-art-b51c21286a304a6dbf9f2eaad0b95cbd |
| institution | Kabale University |
| issn | 1758-3756 1758-3764 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj-art-b51c21286a304a6dbf9f2eaad0b95cbd2024-12-14T16:02:38ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642021-03-011610.15420/ecr.2020.47Role of Inflammation in Coronary Epicardial and Microvascular DysfunctionShigeo Godo0Jun Takahashi1Satoshi Yasuda2Hiroaki Shimokawa3Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanThere is accumulating evidence highlighting a close relationship between inflammation and coronary microvascular dysfunction (CMD) in various experimental and clinical settings, with major clinical implications. Chronic low-grade vascular inflammation plays important roles in the underlying mechanisms behind CMD, especially in patients with coronary artery disease, obesity, heart failure with preserved ejection fraction and chronic inflammatory rheumatoid diseases. The central mechanisms of coronary vasomotion abnormalities comprise enhanced coronary vasoconstrictor reactivity, reduced endothelium-dependent and -independent coronary vasodilator capacity and increased coronary microvascular resistance, where inflammatory mediators and responses are substantially involved. How to modulate CMD to improve clinical outcomes of patients with the disorder and whether CMD management by targeting inflammatory responses can benefit patients remain challenging questions in need of further research. This review provides a concise overview of the current knowledge of the involvement of inflammation in the pathophysiology and molecular mechanisms of CMD from bench to bedside.https://www.ecrjournal.com/articleindex/ecr.2020.47 |
| spellingShingle | Shigeo Godo Jun Takahashi Satoshi Yasuda Hiroaki Shimokawa Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction European Cardiology Review |
| title | Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction |
| title_full | Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction |
| title_fullStr | Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction |
| title_full_unstemmed | Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction |
| title_short | Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction |
| title_sort | role of inflammation in coronary epicardial and microvascular dysfunction |
| url | https://www.ecrjournal.com/articleindex/ecr.2020.47 |
| work_keys_str_mv | AT shigeogodo roleofinflammationincoronaryepicardialandmicrovasculardysfunction AT juntakahashi roleofinflammationincoronaryepicardialandmicrovasculardysfunction AT satoshiyasuda roleofinflammationincoronaryepicardialandmicrovasculardysfunction AT hiroakishimokawa roleofinflammationincoronaryepicardialandmicrovasculardysfunction |