The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer’s Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial
<b>Background</b>: Olive leaves are a significant source of biophenols, which have a beneficial impact on cognitive performance. <b>Objective</b>: To examine, for the first time, in humans the effect of the daily consumption of a beverage containing olive leaf extract (OLE) v...
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MDPI AG
2024-10-01
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| author | Sofia Loukou Georgia Papantoniou Anastasia Pantazaki Magdalini Tsolaki |
| author_facet | Sofia Loukou Georgia Papantoniou Anastasia Pantazaki Magdalini Tsolaki |
| author_sort | Sofia Loukou |
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| description | <b>Background</b>: Olive leaves are a significant source of biophenols, which have a beneficial impact on cognitive performance. <b>Objective</b>: To examine, for the first time, in humans the effect of the daily consumption of a beverage containing olive leaf extract (OLE) versus a Mediterranean diet (MeDi) on patients diagnosed with mild Alzheimer’s Disease (AD), in addition to their regular treatment. <b>Methods</b>: A randomized clinical trial compared OLE’s effects on cognitive and functional performance in 55 mild AD patients. Each participant was randomly assigned to two groups: (1) Group 1 was given olive leaves for making a daily beverage and MeDi instructions through monthly diet programs; (2) Group 2 received only the MeDi instructions. After six months, all participants underwent a second neuropsychological evaluation. <b>Results</b>: Group 1 participants had statistically significantly higher MMSE scores compared to Group 2 with a <i>p</i>-value of 0.0135. Specifically, the mean MMSE difference in patients receiving OLE was close to 0, indicating no memory deterioration, whereas in controls it was −4.1, indicative of cognitive decline. The remaining neuropsychological assessments (FRSSD, FUCAS, ADAS-Cog, CDR, GDS, and NPI) revealed better results in the OLE group, except for GDS, which showed no change, but without statistically significant differences between the two groups. |
| format | Article |
| id | doaj-art-b5118e7c4cf24e6f92792b4f4d0f3487 |
| institution | Kabale University |
| issn | 2035-8377 |
| language | English |
| publishDate | 2024-10-01 |
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| series | Neurology International |
| spelling | doaj-art-b5118e7c4cf24e6f92792b4f4d0f34872024-12-27T14:43:47ZengMDPI AGNeurology International2035-83772024-10-011661247126510.3390/neurolint16060095The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer’s Disease (the GOLDEN Study): A Randomized Controlled Clinical TrialSofia Loukou0Georgia Papantoniou1Anastasia Pantazaki2Magdalini Tsolaki31st Department of Neurology, Medical School, “AHEPA” General Hospital Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Makedonia, 54124 Thessaloniki, GreeceLaboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece1st Department of Neurology, Medical School, “AHEPA” General Hospital Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Makedonia, 54124 Thessaloniki, Greece<b>Background</b>: Olive leaves are a significant source of biophenols, which have a beneficial impact on cognitive performance. <b>Objective</b>: To examine, for the first time, in humans the effect of the daily consumption of a beverage containing olive leaf extract (OLE) versus a Mediterranean diet (MeDi) on patients diagnosed with mild Alzheimer’s Disease (AD), in addition to their regular treatment. <b>Methods</b>: A randomized clinical trial compared OLE’s effects on cognitive and functional performance in 55 mild AD patients. Each participant was randomly assigned to two groups: (1) Group 1 was given olive leaves for making a daily beverage and MeDi instructions through monthly diet programs; (2) Group 2 received only the MeDi instructions. After six months, all participants underwent a second neuropsychological evaluation. <b>Results</b>: Group 1 participants had statistically significantly higher MMSE scores compared to Group 2 with a <i>p</i>-value of 0.0135. Specifically, the mean MMSE difference in patients receiving OLE was close to 0, indicating no memory deterioration, whereas in controls it was −4.1, indicative of cognitive decline. The remaining neuropsychological assessments (FRSSD, FUCAS, ADAS-Cog, CDR, GDS, and NPI) revealed better results in the OLE group, except for GDS, which showed no change, but without statistically significant differences between the two groups.https://www.mdpi.com/2035-8377/16/6/95Alzheimer’s diseaseolive leaf extractMediterranean dietmild dementianatural compounds |
| spellingShingle | Sofia Loukou Georgia Papantoniou Anastasia Pantazaki Magdalini Tsolaki The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer’s Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial Neurology International Alzheimer’s disease olive leaf extract Mediterranean diet mild dementia natural compounds |
| title | The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer’s Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial |
| title_full | The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer’s Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial |
| title_fullStr | The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer’s Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial |
| title_full_unstemmed | The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer’s Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial |
| title_short | The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer’s Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial |
| title_sort | role of greek olive leaf extract in patients with mild alzheimer s disease the golden study a randomized controlled clinical trial |
| topic | Alzheimer’s disease olive leaf extract Mediterranean diet mild dementia natural compounds |
| url | https://www.mdpi.com/2035-8377/16/6/95 |
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