Single cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives

Single cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives

Abstract Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somati...

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Bibliographic Details
Main Authors: Zahra Khosroabadi, Samaneh Azaryar, Hassan Dianat-Moghadam, Zohreh Amoozgar, Mohammadreza Sharifi
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Medicine
Subjects:
AI model
AML
Drug resistance
Single cell RNA sequencing
Tumor heterogeneity
Online Access:https://doi.org/10.1186/s10020-025-01085-w
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