Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning
Neurons are highly differentiated and compartmentalized cells that conduct cellular processes in a spatiotemporally regulated manner. Autophagy in neurons occurs locally under stimulation and contributes to synaptic plasticity. Little is known about the initial steps leading to autophagy upon neuron...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Autophagy Reports |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/27694127.2024.2346064 |
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| author | Aleksandra Janusz-Kaminska Jacek Jaworski |
| author_facet | Aleksandra Janusz-Kaminska Jacek Jaworski |
| author_sort | Aleksandra Janusz-Kaminska |
| collection | DOAJ |
| description | Neurons are highly differentiated and compartmentalized cells that conduct cellular processes in a spatiotemporally regulated manner. Autophagy in neurons occurs locally under stimulation and contributes to synaptic plasticity. Little is known about the initial steps leading to autophagy upon neuronal stimulation and the role of autophagic compartments at the postsynaptic part of the synapse. Here, we summarize our recent manuscript on Rab11 role in autophagy initiation in the dendritic spines. We showed that Rab11 maintains in the dendritic spines Atg9A and is necessary for LC3+ vesicles to emerge at the postsynapse. We hypothesize that autophagosomes arise due to an interplay between NMDA receptor stimulation and local mTOR kinase activity. We suggest that autophagosomes are not, in fact, responsible for dendritic spine pruning. |
| format | Article |
| id | doaj-art-b4cea8d474374d2c917fb21001b51c33 |
| institution | Kabale University |
| issn | 2769-4127 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj-art-b4cea8d474374d2c917fb21001b51c332024-12-09T07:19:32ZengTaylor & Francis GroupAutophagy Reports2769-41272024-12-013110.1080/27694127.2024.2346064Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruningAleksandra Janusz-Kaminska0Jacek Jaworski1Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USALaboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, PolandNeurons are highly differentiated and compartmentalized cells that conduct cellular processes in a spatiotemporally regulated manner. Autophagy in neurons occurs locally under stimulation and contributes to synaptic plasticity. Little is known about the initial steps leading to autophagy upon neuronal stimulation and the role of autophagic compartments at the postsynaptic part of the synapse. Here, we summarize our recent manuscript on Rab11 role in autophagy initiation in the dendritic spines. We showed that Rab11 maintains in the dendritic spines Atg9A and is necessary for LC3+ vesicles to emerge at the postsynapse. We hypothesize that autophagosomes arise due to an interplay between NMDA receptor stimulation and local mTOR kinase activity. We suggest that autophagosomes are not, in fact, responsible for dendritic spine pruning.https://www.tandfonline.com/doi/10.1080/27694127.2024.2346064Atg9ARab11mTORautophagyneuronssynaptic plasticity |
| spellingShingle | Aleksandra Janusz-Kaminska Jacek Jaworski Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning Autophagy Reports Atg9A Rab11 mTOR autophagy neurons synaptic plasticity |
| title | Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning |
| title_full | Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning |
| title_fullStr | Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning |
| title_full_unstemmed | Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning |
| title_short | Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning |
| title_sort | autophagy at the postsynapse begins with rab11 and does not end with dendritic spine pruning |
| topic | Atg9A Rab11 mTOR autophagy neurons synaptic plasticity |
| url | https://www.tandfonline.com/doi/10.1080/27694127.2024.2346064 |
| work_keys_str_mv | AT aleksandrajanuszkaminska autophagyatthepostsynapsebeginswithrab11anddoesnotendwithdendriticspinepruning AT jacekjaworski autophagyatthepostsynapsebeginswithrab11anddoesnotendwithdendriticspinepruning |