Influence of sarcopenia on clinical outcomes in peptic ulcer bleeding: a retrospective single-center analysis in Korea
Background/Aims Peptic ulcer bleeding (PUB) is a major cause of nonvariceal gastrointestinal bleeding. As the older population increases, the prevalence of sarcopenia is also growing. Although sarcopenia influences the prognosis of various diseases, its association with clinical outcomes of PUB rema...
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2025-05-01
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| Series: | Clinical Endoscopy |
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| Online Access: | http://e-ce.org/upload/pdf/ce-2024-209.pdf |
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| author | Ji Hoon Yu Hyun Tak Lee Seok Ki Jang Ah Young Lee Jun-young Seo |
| author_facet | Ji Hoon Yu Hyun Tak Lee Seok Ki Jang Ah Young Lee Jun-young Seo |
| author_sort | Ji Hoon Yu |
| collection | DOAJ |
| description | Background/Aims Peptic ulcer bleeding (PUB) is a major cause of nonvariceal gastrointestinal bleeding. As the older population increases, the prevalence of sarcopenia is also growing. Although sarcopenia influences the prognosis of various diseases, its association with clinical outcomes of PUB remains unknown. Therefore, this study aimed to explore this correlation. Methods We retrospectively analyzed 2,050 patients who underwent esophagogastroduodenoscopy for suspected gastrointestinal bleeding between January 2014 and December 2021. Patients who underwent computed tomography scans were included for sarcopenia evaluation based on the psoas muscle index, defined as the total psoas area normalized by the square of the height of the patient. Sarcopenia was defined using specific cutoffs: ≤7.3 cm2/m2 and ≤5.1 cm2/m2 for men and women, respectively. The primary outcome measured was the 30-day mortality rate. Results Out of 358 patients, 149 were diagnosed with sarcopenia. The 30-day mortality rate was significantly higher in patients with sarcopenia than in those without. Multivariate regression analysis revealed significant associations between sarcopenia, a high age, blood tests, and comorbidity score, and administration of inotropic agents with 30-day mortality. Conclusions Our study showed that the presence of sarcopenia, elevated comorbidity scores, and use of inotropes were associated with higher 30-day mortality rates. Considering that sarcopenia may influence the clinical outcomes in patients with PUB, it is crucial to manage patients with sarcopenia with particular care. |
| format | Article |
| id | doaj-art-b4b95fa8412f42f5bb2ee2d886f3aac1 |
| institution | Kabale University |
| issn | 2234-2400 2234-2443 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj-art-b4b95fa8412f42f5bb2ee2d886f3aac12025-08-20T03:33:25ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432025-05-0158342543710.5946/ce.2024.2097969Influence of sarcopenia on clinical outcomes in peptic ulcer bleeding: a retrospective single-center analysis in KoreaJi Hoon Yu0Hyun Tak Lee1Seok Ki Jang2Ah Young Lee3Jun-young Seo4 Department of Gastroenterology, Bundang Jesaeng General Hospital, Seongnam, Korea Department of Gastroenterology, Bundang Jesaeng General Hospital, Seongnam, Korea Department of Radiology, Bundang Jesaeng General Hospital, Seongnam, Korea Department of Gastroenterology, Cha Gangnam Medical Center, CHA University, Cha University of School of Medicine, Seoul, Korea Department of Gastroenterology, Bundang Jesaeng General Hospital, Seongnam, KoreaBackground/Aims Peptic ulcer bleeding (PUB) is a major cause of nonvariceal gastrointestinal bleeding. As the older population increases, the prevalence of sarcopenia is also growing. Although sarcopenia influences the prognosis of various diseases, its association with clinical outcomes of PUB remains unknown. Therefore, this study aimed to explore this correlation. Methods We retrospectively analyzed 2,050 patients who underwent esophagogastroduodenoscopy for suspected gastrointestinal bleeding between January 2014 and December 2021. Patients who underwent computed tomography scans were included for sarcopenia evaluation based on the psoas muscle index, defined as the total psoas area normalized by the square of the height of the patient. Sarcopenia was defined using specific cutoffs: ≤7.3 cm2/m2 and ≤5.1 cm2/m2 for men and women, respectively. The primary outcome measured was the 30-day mortality rate. Results Out of 358 patients, 149 were diagnosed with sarcopenia. The 30-day mortality rate was significantly higher in patients with sarcopenia than in those without. Multivariate regression analysis revealed significant associations between sarcopenia, a high age, blood tests, and comorbidity score, and administration of inotropic agents with 30-day mortality. Conclusions Our study showed that the presence of sarcopenia, elevated comorbidity scores, and use of inotropes were associated with higher 30-day mortality rates. Considering that sarcopenia may influence the clinical outcomes in patients with PUB, it is crucial to manage patients with sarcopenia with particular care.http://e-ce.org/upload/pdf/ce-2024-209.pdfhemorrhagemortalitypeptic ulcersarcopenia |
| spellingShingle | Ji Hoon Yu Hyun Tak Lee Seok Ki Jang Ah Young Lee Jun-young Seo Influence of sarcopenia on clinical outcomes in peptic ulcer bleeding: a retrospective single-center analysis in Korea Clinical Endoscopy hemorrhage mortality peptic ulcer sarcopenia |
| title | Influence of sarcopenia on clinical outcomes in peptic ulcer bleeding: a retrospective single-center analysis in Korea |
| title_full | Influence of sarcopenia on clinical outcomes in peptic ulcer bleeding: a retrospective single-center analysis in Korea |
| title_fullStr | Influence of sarcopenia on clinical outcomes in peptic ulcer bleeding: a retrospective single-center analysis in Korea |
| title_full_unstemmed | Influence of sarcopenia on clinical outcomes in peptic ulcer bleeding: a retrospective single-center analysis in Korea |
| title_short | Influence of sarcopenia on clinical outcomes in peptic ulcer bleeding: a retrospective single-center analysis in Korea |
| title_sort | influence of sarcopenia on clinical outcomes in peptic ulcer bleeding a retrospective single center analysis in korea |
| topic | hemorrhage mortality peptic ulcer sarcopenia |
| url | http://e-ce.org/upload/pdf/ce-2024-209.pdf |
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