Protocol for detecting homologous recombination activity in cancer cells by adenovirus-based functional assay

Protocol for detecting homologous recombination activity in cancer cells by adenovirus-based functional assay

Summary: Cancer cells with homologous recombination deficiency (HRD) exhibit a distinctive vulnerability to poly(ADP-ribose) polymerase inhibitors (PARPis). To address the limitations of existing methodologies incapable of providing real-time insights into homologous recombination (HR) status, we pr...

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Bibliographic Details
Main Authors: Shih-Han Huang, Chih-Ying Lee, Peter Chi
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:STAR Protocols
Subjects:
cell-based assays
cancer
clinical protocol
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166724005689
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