Therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosis
As a late-onset and fatal neurodegenerative disease that affects upper and lower motor neurons, amyotrophic lateral sclerosis (ALS) is a difficult disease to diagnose and treat, needing further research on mechanisms of pathogenesis. In addition due to difficulties in delivering therapeutics past th...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Extracellular Vesicle |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041722000142 |
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| author | Taylor J. Ellison Steven L. Stice Yao Yao |
| author_facet | Taylor J. Ellison Steven L. Stice Yao Yao |
| author_sort | Taylor J. Ellison |
| collection | DOAJ |
| description | As a late-onset and fatal neurodegenerative disease that affects upper and lower motor neurons, amyotrophic lateral sclerosis (ALS) is a difficult disease to diagnose and treat, needing further research on mechanisms of pathogenesis. In addition due to difficulties in delivering therapeutics past the blood brain barrier (BBB) to target disease-relevant cells in the central nervous system (CNS), diseases like ALS are particularly difficult to manage. However, recent advances in nanomedicine have provided new opportunities. Extracellular vesicles (EVs) are small, spherical, nanosized particles that have shown various applicable properties in the treatment and diagnosis of ALS through inherent characteristics and drug delivery capabilities. Extracellular vesicles with unique cargos determined by cells of origin possess neural protecting qualities and can cross the BBB and deliver endogenous and/or engineered cargo to specific neural cell targets. In this review, we discuss the potential use of EVs as therapeutics, drug delivery systems, and biomarkers for ALS. |
| format | Article |
| id | doaj-art-b4830a51d15544068d467cde10e0fcdd |
| institution | Kabale University |
| issn | 2773-0417 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-b4830a51d15544068d467cde10e0fcdd2024-11-23T06:34:51ZengElsevierExtracellular Vesicle2773-04172023-12-012100019Therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosisTaylor J. Ellison0Steven L. Stice1Yao Yao2Regenerative Bioscience Center, University of Georgia, Athens, GA, United States of America; Department of Animal and Dairy Science, University of Georgia, Athens, GA, United States of AmericaRegenerative Bioscience Center, University of Georgia, Athens, GA, United States of America; Biomedical Health and Sciences Institute, Division of Neuroscience, University of Georgia, Athens, GA, United States of America; Department of Animal and Dairy Science, University of Georgia, Athens, GA, United States of AmericaRegenerative Bioscience Center, University of Georgia, Athens, GA, United States of America; Biomedical Health and Sciences Institute, Division of Neuroscience, University of Georgia, Athens, GA, United States of America; Department of Animal and Dairy Science, University of Georgia, Athens, GA, United States of America; Corresponding author at: Regenerative Bioscience Center, University of Georgia, Athens, GA, United States of America.As a late-onset and fatal neurodegenerative disease that affects upper and lower motor neurons, amyotrophic lateral sclerosis (ALS) is a difficult disease to diagnose and treat, needing further research on mechanisms of pathogenesis. In addition due to difficulties in delivering therapeutics past the blood brain barrier (BBB) to target disease-relevant cells in the central nervous system (CNS), diseases like ALS are particularly difficult to manage. However, recent advances in nanomedicine have provided new opportunities. Extracellular vesicles (EVs) are small, spherical, nanosized particles that have shown various applicable properties in the treatment and diagnosis of ALS through inherent characteristics and drug delivery capabilities. Extracellular vesicles with unique cargos determined by cells of origin possess neural protecting qualities and can cross the BBB and deliver endogenous and/or engineered cargo to specific neural cell targets. In this review, we discuss the potential use of EVs as therapeutics, drug delivery systems, and biomarkers for ALS.http://www.sciencedirect.com/science/article/pii/S2773041722000142Extracellular vesiclesALSTherapeuticsCNS deliveryBiomarker |
| spellingShingle | Taylor J. Ellison Steven L. Stice Yao Yao Therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosis Extracellular Vesicle Extracellular vesicles ALS Therapeutics CNS delivery Biomarker |
| title | Therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosis |
| title_full | Therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosis |
| title_fullStr | Therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosis |
| title_full_unstemmed | Therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosis |
| title_short | Therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosis |
| title_sort | therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosis |
| topic | Extracellular vesicles ALS Therapeutics CNS delivery Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2773041722000142 |
| work_keys_str_mv | AT taylorjellison therapeuticanddiagnosticpotentialofextracellularvesiclesinamyotrophiclateralsclerosis AT stevenlstice therapeuticanddiagnosticpotentialofextracellularvesiclesinamyotrophiclateralsclerosis AT yaoyao therapeuticanddiagnosticpotentialofextracellularvesiclesinamyotrophiclateralsclerosis |