Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study
Abstract Background Alcohol intake is associated with a higher risk of estrogen receptor-positive (ER+) breast cancer (BC), presumably through its confirmed ability to increase sex hormone levels. Whether consuming alcohol within the recommended limit of one serving per day increases sex hormone lev...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Breast Cancer Research |
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| Online Access: | https://doi.org/10.1186/s13058-024-01940-4 |
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| author | Elizabeth Mostofsky Julie E. Buring Steven E. Come Nadine M. Tung Cancan Zhang Kenneth J. Mukamal |
| author_facet | Elizabeth Mostofsky Julie E. Buring Steven E. Come Nadine M. Tung Cancan Zhang Kenneth J. Mukamal |
| author_sort | Elizabeth Mostofsky |
| collection | DOAJ |
| description | Abstract Background Alcohol intake is associated with a higher risk of estrogen receptor-positive (ER+) breast cancer (BC), presumably through its confirmed ability to increase sex hormone levels. Whether consuming alcohol within the recommended limit of one serving per day increases sex hormone levels among postmenopausal women taking aromatase inhibitors (AI) to inhibit estrogen production remains unknown. Therefore, we compared sex hormone levels following white wine to levels following white grape juice among ER + BC survivors taking AIs. Methods In this 10-week randomized controlled two-period crossover trial conducted from September 2022 to July 2023 among 20 postmenopausal women on AIs, we examined within-person changes in sex hormone levels following 3 weeks of 5 ounces of white wine daily versus 3 weeks of 6 ounces of white grape juice daily, with each drinking period preceded by two-week washouts and drinking period sequence allocated by randomization. Results All 20 participants completed the trial. Compared to daily grape juice, daily wine led to decreases in total estradiol (11.1%, 95%confidence interval[CI] -49.8%,57.2%), free estradiol index (0.7%, 95%CI -2%,0.7%), and free estradiol concentration (7.7%, 95%CI -48%, 63.9%) but increases in estrone (13.8%, 95%CI -9.5%,43.1%), dehydroepiandrosterone sulfate (DHEAS; 11.4%, 95%CI -3.3%,28.4%), and testosterone (12.6%, 95%CI -0.8%,27.7%) and decreased sex hormone-binding globulin (SHBG; -2.7%, 95%CI -21.9%,21.2%). Conclusions Five ounces of white wine daily did not lead to statistically significant increases in estradiol, but it led to changes in other sex hormones suggesting higher BC risk. Whether this level of alcohol intake diminishes AI effectiveness warrants further investigation. Trials Registration Clinicaltrials.gov NCT05423730 registered June 14, 2022. |
| format | Article |
| id | doaj-art-b46e30879f7148c39e312106f7d3a11b |
| institution | Kabale University |
| issn | 1465-542X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj-art-b46e30879f7148c39e312106f7d3a11b2025-01-12T12:45:32ZengBMCBreast Cancer Research1465-542X2025-01-0127111010.1186/s13058-024-01940-4Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot studyElizabeth Mostofsky0Julie E. Buring1Steven E. Come2Nadine M. Tung3Cancan Zhang4Kenneth J. Mukamal5Department of Epidemiology (EM, JEB) and Nutrition (KJM), Harvard T.H. Chan School of Public HealthDepartment of Epidemiology (EM, JEB) and Nutrition (KJM), Harvard T.H. Chan School of Public HealthDepartment of Medicine (SEC, NMT, CZ, KJM), Beth Israel Deaconess Medical Center, Harvard Medical, SchoolCancer Risk and Prevention Program and Breast Medical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical, SchoolDepartment of Medicine (SEC, NMT, CZ, KJM), Beth Israel Deaconess Medical Center, Harvard Medical, SchoolDepartment of Epidemiology (EM, JEB) and Nutrition (KJM), Harvard T.H. Chan School of Public HealthAbstract Background Alcohol intake is associated with a higher risk of estrogen receptor-positive (ER+) breast cancer (BC), presumably through its confirmed ability to increase sex hormone levels. Whether consuming alcohol within the recommended limit of one serving per day increases sex hormone levels among postmenopausal women taking aromatase inhibitors (AI) to inhibit estrogen production remains unknown. Therefore, we compared sex hormone levels following white wine to levels following white grape juice among ER + BC survivors taking AIs. Methods In this 10-week randomized controlled two-period crossover trial conducted from September 2022 to July 2023 among 20 postmenopausal women on AIs, we examined within-person changes in sex hormone levels following 3 weeks of 5 ounces of white wine daily versus 3 weeks of 6 ounces of white grape juice daily, with each drinking period preceded by two-week washouts and drinking period sequence allocated by randomization. Results All 20 participants completed the trial. Compared to daily grape juice, daily wine led to decreases in total estradiol (11.1%, 95%confidence interval[CI] -49.8%,57.2%), free estradiol index (0.7%, 95%CI -2%,0.7%), and free estradiol concentration (7.7%, 95%CI -48%, 63.9%) but increases in estrone (13.8%, 95%CI -9.5%,43.1%), dehydroepiandrosterone sulfate (DHEAS; 11.4%, 95%CI -3.3%,28.4%), and testosterone (12.6%, 95%CI -0.8%,27.7%) and decreased sex hormone-binding globulin (SHBG; -2.7%, 95%CI -21.9%,21.2%). Conclusions Five ounces of white wine daily did not lead to statistically significant increases in estradiol, but it led to changes in other sex hormones suggesting higher BC risk. Whether this level of alcohol intake diminishes AI effectiveness warrants further investigation. Trials Registration Clinicaltrials.gov NCT05423730 registered June 14, 2022.https://doi.org/10.1186/s13058-024-01940-4AlcoholEthanolEstrogen receptor-positive (ER+) breast cancerSex hormonesAromatase inhibitorsCrossover trial |
| spellingShingle | Elizabeth Mostofsky Julie E. Buring Steven E. Come Nadine M. Tung Cancan Zhang Kenneth J. Mukamal Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study Breast Cancer Research Alcohol Ethanol Estrogen receptor-positive (ER+) breast cancer Sex hormones Aromatase inhibitors Crossover trial |
| title | Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study |
| title_full | Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study |
| title_fullStr | Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study |
| title_full_unstemmed | Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study |
| title_short | Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study |
| title_sort | effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy a randomized controlled crossover pilot study |
| topic | Alcohol Ethanol Estrogen receptor-positive (ER+) breast cancer Sex hormones Aromatase inhibitors Crossover trial |
| url | https://doi.org/10.1186/s13058-024-01940-4 |
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