FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis

FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis

BackgroundIdiopathic Pulmonary Fibrosis (IPF), an interstitial lung disease of unknown etiology, remains incurable with current therapies, which fail to halt disease progression or restore lung function. However, Feibi Recipe No. 2 (FBR2), a clinically validated traditional Chinese medicine formula,...

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Bibliographic Details
Main Authors: Yu Cheng, Yang Jiao, Wan Wei, Mengjia Kou, Yaodong Cai, Yang Li, Hao Li, Tonghua Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
bleomycin
Chinese medicine
FBR2
ferroptosis
SIRT3/p53 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1509665/full
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