Dual antioxidant and cytotoxic activities of novel 1,2,3-triazole-decorated unsymmetrical monocarbonyl curcumin analogs

Dual antioxidant and cytotoxic activities of novel 1,2,3-triazole-decorated unsymmetrical monocarbonyl curcumin analogs

Unsymmetrical monocarbonyl curcumin analogs containing 1,2,3-triazole scaffold (5a-5f) have been synthesized from vanillin. 5d, which contains a carboxylic group, exhibited the highest antioxidant and cytotoxic activities, with an IC50 of 0.56 mM against DPPH and an IC50 of 38.25 ± 4.79 μM against M...

Full description

Saved in:

Bibliographic Details
Main Authors:	Bayu Ardiansah, Ahmad Farhan, Novita Sari Nurhasanah, Mochammad Arfin Fardiansyah Nasution, Noordini M. Salleh, Kenji Mizuguchi, Antonius Herry Cahyana, Lina Mardiana
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Series:	Case Studies in Chemical and Environmental Engineering
Subjects:	Curcumin analogs 1,2,3-triazole Hybrid compounds Cytotoxic Antioxidant
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666016424004250
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis, biological screening, and in silico physicochemical analysis of novel 1,2,3-triazolyl oleate esters
by: Hilna Diana Sahaya, et al.
Published: (2024-12-01)

Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation
by: Rezki Nadjet, et al.
Published: (2017-09-01)

Quinoline-thiosemicarbazone-1,2,3-triazole-acetamide derivatives as new potent α-glucosidase inhibitors
by: Aynaz Khademian, et al.
Published: (2024-12-01)

Design, Synthesis, Characterization and antibacterial activity of new 1,2,3-triazole linked nucleosides
by: Aditya Aggarwal, et al.
Published: (2024-12-01)

Anti-cancer activity of synthetic gefitinib-1,2,3-triazole derivatives against Hela cells via induction of apoptosis
by: Zhihong Hu, et al.
Published: (2025-01-01)

Exploring of N-phthalimide-linked 1,2,3-triazole analogues with promising anti-SARS-CoV-2 activity: synthesis, biological screening, and molecular modelling studies
by: Ateyatallah Aljuhani, et al.
Published: (2024-12-01)

Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway
by: Su Qing, et al.
Published: (2022-09-01)

Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis
by: Manisha Singh, et al.
Published: (2024-12-01)

Biological importance and synthesis of 1,2,3-triazole derivatives: a review
by: Mira J. Vaishnani, et al.
Published: (2024-12-01)

Recent Developments Towards the Synthesis of Triazole Derivatives: A Review
by: Issam Ameziane El Hassani, et al.
Published: (2024-10-01)

Synthesis, crystal structure, Hirshfeld surface analysis, and DFT calculation of 4-(5-(((1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine
by: Mohamed El-Naggar, et al.
Published: (2024-11-01)

Synthesis of Novel Gefitinib-Conjugated 1,2,3-Triazole Derivatives and Their Effect of Inducing DNA Damage and Apoptosis in Tumor Cells
by: Junfei Wu, et al.
Published: (2024-11-01)

Novel coumarin-based acetohydrazide-1,2,3-triazole derivatives as urease enzyme inhibitors: Synthesis, in vitro evaluation, and molecular dynamics simulation studies
by: Hassan Sepehrmansourie, et al.
Published: (2025-01-01)

Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1<i>H</i>-1,2,3-triazoles: A Review of Their Anticancer Activity
by: Delia Hernández-Romero, et al.
Published: (2024-11-01)

Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors
by: Alshimaa A. Y. Ahmed, et al.
Published: (2025-01-01)

Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells
by: Xixi Hou, et al.
Published: (2025-01-01)

Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus
by: Youssif Bahaa G. M., et al.
Published: (2016-06-01)

Effects of 1<i>H</i>-1,2,3-Triazole Derivatives of 3-<i>O</i>-Acetyl-11-Keto-Beta-Boswellic Acid from <i>Boswellia sacra</i> Resin on T-Cell Proliferation and Activation
by: Abdo Meyiah, et al.
Published: (2024-12-01)

(4a<i>S</i>,5S,6a<i>R</i>,10a<i>R</i>,10b<i>R</i>)-5-Methoxy-9,9-dimethyl-4a,5,6a,7,10a,10b-hexahydro-12<i>H</i>-[1,3]dioxino[4′,5′:5,6]pyrano[4,3-b][1,2,3]triazolo[1,5-d][1,4]oxazine
by: Leticia Lomas Romero, et al.
Published: (2024-10-01)

Reaction of 4-acetyl-1,2,3-triazol-5-olate with hydrazine derivatives
by: I. S. Khazhieva, et al.
Published: (2015-03-01)

Aniline Derivatives Containing 1-Substituted 1,2,3-Triazole System as Potential Drug Candidates: Pharmacokinetic Profile Prediction, Lipophilicity Analysis Using Experimental and In Silico Studies
by: Elwira Chrobak, et al.
Published: (2024-11-01)

Design, Synthesis, enzyme inhibitory activity and molecular docking studies of new 1,2,3-triazole linked nucleobases
by: Aditya Aggarwal, et al.
Published: (2025-01-01)

Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors
by: Mohamed A. Mahmoud, et al.
Published: (2024-12-01)

Aldehyde Phenylamino-Pyrimidine as Key Precursor for the Synthesis of Imatinib Analogs and In Silico Studies of Their Intermediates
by: Luz E. Tierrablanca-Arias, et al.
Published: (2023-11-01)

Iodine-123 Metaiodobenzylguanidine (I-123 MIBG) in Clinical Applications: A Comprehensive Review
by: Ming-Cheng Chang, et al.
Published: (2024-11-01)

The thiazole and triazole derivatives as inhibitors of metal corrosion: Part II
by: Đenđi Vaštag, et al.
Published: (2016-06-01)

Understanding the impact of triazoles on female fertility and embryo development: Mechanisms and implications
by: Sonal Sharma, et al.
Published: (2025-06-01)

Inhibition of Giardia duodenalis by isocryptolepine -triazole adducts and derivatives
by: Supaluk Popruk, et al.
Published: (2024-12-01)

Antiviral Activity of (1<i>S</i>,9a<i>R</i>)-1-[(1,2,3-Triazol-1-yl)methyl]octahydro-1<i>H</i>-quinolizines from the Alkaloid Lupinine
by: Zhangeldy S. Nurmaganbetov, et al.
Published: (2024-12-01)

The thiazole and triazole derivatives as inhibitors of metal corrosion: Part I
by: Jelena Nakomčić, et al.
Published: (2016-06-01)

Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia
by: Haotian Ma, et al.
Published: (2024-11-01)

Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling
by: John M. Halford-McGuff, et al.
Published: (2024-12-01)

Antistaphylococcal Triazole-Based Molecular Hybrids: Design, Synthesis and Activity
by: Kostiantyn Shabelnyk, et al.
Published: (2025-01-01)

Comparative assessment of stability of fungicides triazolopyrimidine, triazole, pyrimidine and morpholine in the soil and prediction of groundwater pollution with them
by: Bіlous S.V., et al.
Published: (2016-03-01)

Comparative assessment of stability of fungicides triazolopyrimidine, triazole, pyrimidine and morpholine in the soil and prediction of groundwater pollution with them.
by: S. V. Bіlous, et al.
Published: (2016-03-01)

Ionic quaternary ammonium-triazole polymers as efficient single-component catalysts for CO2 conversion
by: Pobporn Promchan, et al.
Published: (2024-12-01)

Sulfur Derivatives of 1,2,4-Triazole: Recently Developed Compounds, Structure Activity Relationship, and Biological Activity: Review article
by: Azhar Mahdi Jasim, et al.
Published: (2024-12-01)

One-Pot Synthesis of Tetrazole–Triazole <i>Bis</i>-Heterocycles via Ugi–Azide Reaction
by: Fidel Rodriguez-Lopez, et al.
Published: (2023-11-01)

Synthesis and Biological Evaluation of New <i>cis</i>-Restricted Triazole Analogues of Combretastatin A-4
by: Lidia Prieto, et al.
Published: (2025-01-01)

In vitro Biological Evaluation of 1,2,4-triazole Mannich Base
by: Mahmood Sherzad Rafaat, et al.
Published: (2023-12-01)