Comparison between the levels of anti mullerian hormone after treatment with clomid versus letrozole in polycystic women: an experimental study
Objective: To compare the effect of two ovulation induction drugs on anti-Mullerian hormone level in polycystic women. Method: The experimental cohort study was done at the infertility outpatient clinics of Al-Yarmouk Teaching Hospital, Baghdad, Iraq, from May 2020 to April 2021, and comprised i...
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Pakistan Medical Association
2024-09-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/21798 |
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| author | Manal Madany Abdel Qader Shatha Sami Hussein Huda Fadhil Jadi |
| author_facet | Manal Madany Abdel Qader Shatha Sami Hussein Huda Fadhil Jadi |
| author_sort | Manal Madany Abdel Qader |
| collection | DOAJ |
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Objective: To compare the effect of two ovulation induction drugs on anti-Mullerian hormone level in polycystic women.
Method: The experimental cohort study was done at the infertility outpatient clinics of Al-Yarmouk Teaching Hospital, Baghdad, Iraq, from May 2020 to April 2021, and comprised infertile women aged 18-35 years with confirmed diagnosis of polycystic ovarian syndrome. Baseline blood level of anti-Mullerian hormone was tested in all patients. The patients were divided into two groups. Group A patients received clomid 50mg twice daily to a maximum of 200mg for 5 days starting from the third day of the menstrual cycle. Group B patients received letrozole 2.5mg twice daily for 5 days starting from the third day of the menstrual cycle. After ovulation induction on day 12-14, a second sample of serum anti-Mullerian hormone was tested, and intergroup comparisons were done. Data were analysed by using the available statistical package of SPSS-28 (Statistical Packages for Social Sciences- version 28). Students-t-test , Paired-t-test , Pearson correlation , t-test or ANOVA test Statistical significance was considered for P value equal or less than 0.05.
Results: Of the 83 women, 41(49.4%) were in Group A with mean age 26.0±4.9 years, while Group B had 42(50.6%) subjects with mean age 27.0±5.1 years. Post-intervention, the level of anti-Mullerian hormone decreased significantly in both groups (p<0.05). The decrease in Group B was more than Group A, but the difference was not significant (p>0.05).
Conclusions: Ovulation induction drugs clomid and leterzole decreased the level of anti-Mullerian hormone significantly.
Key Words: Polycystic Ovary, Anti-Mullerian Hormone, Letrozole, Infertility, Ovulation Induction, Ambulatory Care, Menstrual Cycle, Clomiphene
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| format | Article |
| id | doaj-art-b4479c29b70c40d7b9d0a55814bce7b8 |
| institution | Kabale University |
| issn | 0030-9982 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj-art-b4479c29b70c40d7b9d0a55814bce7b82025-08-20T03:40:01ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822024-09-017410 (Supple-08)10.47391/JPMA-BAGH-16-21Comparison between the levels of anti mullerian hormone after treatment with clomid versus letrozole in polycystic women: an experimental studyManal Madany Abdel Qader0Shatha Sami Hussein1Huda Fadhil Jadi2Department of Obstetrics and Gynaecology, Mustansiriyah University, Baghdad, Iraq.Department of Obstetrics and Gynaecology, Mustansiriyah University, Baghdad, Iraq.Department of Obstetrics and Gynaecology, Fatima Al-Zahraa Hospital, Baghdad, Iraq. Objective: To compare the effect of two ovulation induction drugs on anti-Mullerian hormone level in polycystic women. Method: The experimental cohort study was done at the infertility outpatient clinics of Al-Yarmouk Teaching Hospital, Baghdad, Iraq, from May 2020 to April 2021, and comprised infertile women aged 18-35 years with confirmed diagnosis of polycystic ovarian syndrome. Baseline blood level of anti-Mullerian hormone was tested in all patients. The patients were divided into two groups. Group A patients received clomid 50mg twice daily to a maximum of 200mg for 5 days starting from the third day of the menstrual cycle. Group B patients received letrozole 2.5mg twice daily for 5 days starting from the third day of the menstrual cycle. After ovulation induction on day 12-14, a second sample of serum anti-Mullerian hormone was tested, and intergroup comparisons were done. Data were analysed by using the available statistical package of SPSS-28 (Statistical Packages for Social Sciences- version 28). Students-t-test , Paired-t-test , Pearson correlation , t-test or ANOVA test Statistical significance was considered for P value equal or less than 0.05. Results: Of the 83 women, 41(49.4%) were in Group A with mean age 26.0±4.9 years, while Group B had 42(50.6%) subjects with mean age 27.0±5.1 years. Post-intervention, the level of anti-Mullerian hormone decreased significantly in both groups (p<0.05). The decrease in Group B was more than Group A, but the difference was not significant (p>0.05). Conclusions: Ovulation induction drugs clomid and leterzole decreased the level of anti-Mullerian hormone significantly. Key Words: Polycystic Ovary, Anti-Mullerian Hormone, Letrozole, Infertility, Ovulation Induction, Ambulatory Care, Menstrual Cycle, Clomiphene https://jpma.org.pk/index.php/public_html/article/view/21798 |
| spellingShingle | Manal Madany Abdel Qader Shatha Sami Hussein Huda Fadhil Jadi Comparison between the levels of anti mullerian hormone after treatment with clomid versus letrozole in polycystic women: an experimental study Journal of the Pakistan Medical Association |
| title | Comparison between the levels of anti mullerian hormone after treatment with clomid versus letrozole in polycystic women: an experimental study |
| title_full | Comparison between the levels of anti mullerian hormone after treatment with clomid versus letrozole in polycystic women: an experimental study |
| title_fullStr | Comparison between the levels of anti mullerian hormone after treatment with clomid versus letrozole in polycystic women: an experimental study |
| title_full_unstemmed | Comparison between the levels of anti mullerian hormone after treatment with clomid versus letrozole in polycystic women: an experimental study |
| title_short | Comparison between the levels of anti mullerian hormone after treatment with clomid versus letrozole in polycystic women: an experimental study |
| title_sort | comparison between the levels of anti mullerian hormone after treatment with clomid versus letrozole in polycystic women an experimental study |
| url | https://jpma.org.pk/index.php/public_html/article/view/21798 |
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