Advanced treatment-resistant ovarian germ cell tumor (yolk sac tumor) with successful fertility realization 20 years after combined treatment: a case report
Background. Yolk sac tumors (YST) are classified as rare malignant germ cell tumors of the ovaries, most commonly found in young patients interested in preserving fertility. YST is characterized by large size, predominantly unilateral involvement, and increased production of alpha-fetoprotein, which...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2024-11-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/3287 |
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| author | E. A. Ulrikh Yu. A. Chekina K. V. Safronova G. M. Teletaeva A. D. Dzharbaeva A. F. Urmancheeva |
| author_facet | E. A. Ulrikh Yu. A. Chekina K. V. Safronova G. M. Teletaeva A. D. Dzharbaeva A. F. Urmancheeva |
| author_sort | E. A. Ulrikh |
| collection | DOAJ |
| description | Background. Yolk sac tumors (YST) are classified as rare malignant germ cell tumors of the ovaries, most commonly found in young patients interested in preserving fertility. YST is characterized by large size, predominantly unilateral involvement, and increased production of alpha-fetoprotein, which can be used as an important diagnostic criterion for this condition. Among all germ cell tumors, YST has the least favorable prognosis. The primary goals of YST treatment are not only to improve prognosis and quality of life but also to enable the patient to fulfill her reproductive plans in the future.Description of the clinical case. We present a clinical case of an aggressive course of yolk sac tumor in the ovary of a 15-year-old girl, requiring multiple surgeries, repeated courses of high-dose drug therapy, and bone marrow transplantation.Conclusion. This is a rare case of YST with successful preservation of reproductive function due to modern medical technologies despite aggressive treatment. |
| format | Article |
| id | doaj-art-b44646268c864514a396cd3b514e7bc3 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2024-11-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-b44646268c864514a396cd3b514e7bc32025-08-20T03:56:41ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682024-11-0123517618410.21294/1814-4861-2024-23-5-176-1841285Advanced treatment-resistant ovarian germ cell tumor (yolk sac tumor) with successful fertility realization 20 years after combined treatment: a case reportE. A. Ulrikh0Yu. A. Chekina1K. V. Safronova2G. M. Teletaeva3A. D. Dzharbaeva4A. F. Urmancheeva5World-Class Research Centre for Personalized Medicine, V.A. Almazov National Medical Research Center; N.N. Petrov National Medical Oncology Research Center of the Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University of the Ministry of Health of RussiaWorld-Class Research Centre for Personalized Medicine, V.A. Almazov National Medical Research CenterN.N. Petrov National Medical Oncology Research Center of the Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University of the Ministry of Health of RussiaN.N. Petrov National Medical Oncology Research Center of the Ministry of Health of RussiaWorld-Class Research Centre for Personalized Medicine, V.A. Almazov National Medical Research CenterN.N. Petrov National Medical Oncology Research Center of the Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University of the Ministry of Health of RussiaBackground. Yolk sac tumors (YST) are classified as rare malignant germ cell tumors of the ovaries, most commonly found in young patients interested in preserving fertility. YST is characterized by large size, predominantly unilateral involvement, and increased production of alpha-fetoprotein, which can be used as an important diagnostic criterion for this condition. Among all germ cell tumors, YST has the least favorable prognosis. The primary goals of YST treatment are not only to improve prognosis and quality of life but also to enable the patient to fulfill her reproductive plans in the future.Description of the clinical case. We present a clinical case of an aggressive course of yolk sac tumor in the ovary of a 15-year-old girl, requiring multiple surgeries, repeated courses of high-dose drug therapy, and bone marrow transplantation.Conclusion. This is a rare case of YST with successful preservation of reproductive function due to modern medical technologies despite aggressive treatment.https://www.siboncoj.ru/jour/article/view/3287germ cell tumorsyolk sac tumoraggressive diseasealpha-fetoproteinfertility preservationhigh-dose chemotherapymedical technologies |
| spellingShingle | E. A. Ulrikh Yu. A. Chekina K. V. Safronova G. M. Teletaeva A. D. Dzharbaeva A. F. Urmancheeva Advanced treatment-resistant ovarian germ cell tumor (yolk sac tumor) with successful fertility realization 20 years after combined treatment: a case report Сибирский онкологический журнал germ cell tumors yolk sac tumor aggressive disease alpha-fetoprotein fertility preservation high-dose chemotherapy medical technologies |
| title | Advanced treatment-resistant ovarian germ cell tumor (yolk sac tumor) with successful fertility realization 20 years after combined treatment: a case report |
| title_full | Advanced treatment-resistant ovarian germ cell tumor (yolk sac tumor) with successful fertility realization 20 years after combined treatment: a case report |
| title_fullStr | Advanced treatment-resistant ovarian germ cell tumor (yolk sac tumor) with successful fertility realization 20 years after combined treatment: a case report |
| title_full_unstemmed | Advanced treatment-resistant ovarian germ cell tumor (yolk sac tumor) with successful fertility realization 20 years after combined treatment: a case report |
| title_short | Advanced treatment-resistant ovarian germ cell tumor (yolk sac tumor) with successful fertility realization 20 years after combined treatment: a case report |
| title_sort | advanced treatment resistant ovarian germ cell tumor yolk sac tumor with successful fertility realization 20 years after combined treatment a case report |
| topic | germ cell tumors yolk sac tumor aggressive disease alpha-fetoprotein fertility preservation high-dose chemotherapy medical technologies |
| url | https://www.siboncoj.ru/jour/article/view/3287 |
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