Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters

Abstract Background Autistic individuals often have difficulty flexibly adjusting their behavior. However, laboratory experiments have yielded inconsistent results, potentially due to various influencing factors, which need to be examined in detail. This study aimed to investigate the hypothesis tha...

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Main Authors: Adeline Lacroix, Yoann Bennetot-Deveria, Monica Baciu, Frédéric Dutheil, Valentin Magnon, Marie Gomot, Martial Mermillod
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Autism
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Online Access:https://doi.org/10.1186/s13229-024-00622-4
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author Adeline Lacroix
Yoann Bennetot-Deveria
Monica Baciu
Frédéric Dutheil
Valentin Magnon
Marie Gomot
Martial Mermillod
author_facet Adeline Lacroix
Yoann Bennetot-Deveria
Monica Baciu
Frédéric Dutheil
Valentin Magnon
Marie Gomot
Martial Mermillod
author_sort Adeline Lacroix
collection DOAJ
description Abstract Background Autistic individuals often have difficulty flexibly adjusting their behavior. However, laboratory experiments have yielded inconsistent results, potentially due to various influencing factors, which need to be examined in detail. This study aimed to investigate the hypothesis that the social content of stimuli could play a specific role in some of the flexibility challenges faced by autistic individuals. The second aim was to explore sex differences in this context. Methods We analyzed data from 256 adult participants (124 with autism), matched on age, gender, and sex, who performed an emotional shifting task involving unpredictable shifts between positive and negative stimuli. Additionally, the task included both social and non-social conditions. Results Our results revealed a larger switch cost in the social than in the non-social condition, and this was more pronounced in autistic than in non-autistic individuals. Furthermore, we observed that autistic females differed from autistic males in the non-social condition and from non-autistic females in the social condition. Limitations The online nature of the study reduced the control over participant conditions. In addition, further studies are needed to investigate whether these results apply to the broader autism spectrum. Conclusions Building on previous research demonstrating a greater switch cost in autistic than non-autistic individuals for socio-emotional stimuli, our study further extends these findings by highlighting that the social context, rather than the emotional nature of the stimuli alone, may play a significant role in the flexibility challenges faced by autistic individuals. Our findings also contribute to the literature on sex differences in autism.
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spelling doaj-art-b43b2cd89565407a80e4c6880f2a353b2024-11-24T12:28:48ZengBMCMolecular Autism2040-23922024-11-0115111210.1186/s13229-024-00622-4Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context mattersAdeline Lacroix0Yoann Bennetot-Deveria1Monica Baciu2Frédéric Dutheil3Valentin Magnon4Marie Gomot5Martial Mermillod6Laboratoire de Psychologie et NeuroCognition, Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRSLaboratoire de Psychologie et NeuroCognition, Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRSLaboratoire de Psychologie et NeuroCognition, Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRSUniversité Clermont Auvergne, CNRS, CHU Clermont-FerrandUniversité Clermont Auvergne, CNRS, CHU Clermont-FerrandINSERM, Imaging Brain and Neuropsychiatry iBraiN U1253, Université de ToursLaboratoire de Psychologie et NeuroCognition, Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRSAbstract Background Autistic individuals often have difficulty flexibly adjusting their behavior. However, laboratory experiments have yielded inconsistent results, potentially due to various influencing factors, which need to be examined in detail. This study aimed to investigate the hypothesis that the social content of stimuli could play a specific role in some of the flexibility challenges faced by autistic individuals. The second aim was to explore sex differences in this context. Methods We analyzed data from 256 adult participants (124 with autism), matched on age, gender, and sex, who performed an emotional shifting task involving unpredictable shifts between positive and negative stimuli. Additionally, the task included both social and non-social conditions. Results Our results revealed a larger switch cost in the social than in the non-social condition, and this was more pronounced in autistic than in non-autistic individuals. Furthermore, we observed that autistic females differed from autistic males in the non-social condition and from non-autistic females in the social condition. Limitations The online nature of the study reduced the control over participant conditions. In addition, further studies are needed to investigate whether these results apply to the broader autism spectrum. Conclusions Building on previous research demonstrating a greater switch cost in autistic than non-autistic individuals for socio-emotional stimuli, our study further extends these findings by highlighting that the social context, rather than the emotional nature of the stimuli alone, may play a significant role in the flexibility challenges faced by autistic individuals. Our findings also contribute to the literature on sex differences in autism.https://doi.org/10.1186/s13229-024-00622-4AutismSocial processingEmotional processingFlexibilityPredictive codingSex differences
spellingShingle Adeline Lacroix
Yoann Bennetot-Deveria
Monica Baciu
Frédéric Dutheil
Valentin Magnon
Marie Gomot
Martial Mermillod
Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters
Molecular Autism
Autism
Social processing
Emotional processing
Flexibility
Predictive coding
Sex differences
title Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters
title_full Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters
title_fullStr Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters
title_full_unstemmed Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters
title_short Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters
title_sort understanding cognitive flexibility in emotional evaluation in autistic males and females the social context matters
topic Autism
Social processing
Emotional processing
Flexibility
Predictive coding
Sex differences
url https://doi.org/10.1186/s13229-024-00622-4
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