Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction
Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. In addition, SIRT2, as the only sirtuin protein colocalized with tubulin in the cytoplasm, has its own functio...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2022/9282484 |
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| author | Changhui Zhu Xue Dong Xiwei Wang Yingying Zheng Juanjuan Qiu Yanling Peng Jiajun Xu Zhengbin Chai Chunyan Liu |
| author_facet | Changhui Zhu Xue Dong Xiwei Wang Yingying Zheng Juanjuan Qiu Yanling Peng Jiajun Xu Zhengbin Chai Chunyan Liu |
| author_sort | Changhui Zhu |
| collection | DOAJ |
| description | Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. In addition, SIRT2, as the only sirtuin protein colocalized with tubulin in the cytoplasm, has its own functions and characteristics. In recent years, studies have increasingly shown that SIRT2 can participate in the regulation of gene expression and regulate signal transduction in the metabolic pathway mainly through its post-translational modification of target genes; thus, SIRT2 has become a key centre in the metabolic pathway and participates in the pathological process of metabolic disorder-related diseases. In this paper, it is discussed that SIRT2 can regulate all aspects of gene expression, including epigenetic modification, replication, transcription and translation, and post-translational modification, which enables SIRT2 to participate in energy metabolism in life activities, and it is clarified that SIRT2 is involved in metabolic process-specific signal transduction mechanisms. Therefore, SIRT2 can be involved in metabolic disorder-related inflammation and oxidative stress, thereby triggering the occurrence of metabolic disorder-related diseases, such as neurodegenerative diseases, tumours, diabetes, and cardiovascular diseases. Currently, although the role of SIRT2 in some diseases is still controversial, given the multiple roles of SIRT2 in regulating physiological and pathological signal transduction, SIRT2 has become a key target for disease treatment. It is believed that with increasing research, the clinical application of SIRT2 will be promoted. |
| format | Article |
| id | doaj-art-b42aeee73de54dba9cda16326a1d1543 |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-b42aeee73de54dba9cda16326a1d15432025-02-03T07:21:40ZengWileyGenetics Research1469-50732022-01-01202210.1155/2022/9282484Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal TransductionChanghui Zhu0Xue Dong1Xiwei Wang2Yingying Zheng3Juanjuan Qiu4Yanling Peng5Jiajun Xu6Zhengbin Chai7Chunyan Liu8Department of Biochemistry and Molecular BiologyDepartment of EducationDepartment of AnesthesiologyMedical Research CenterShandong First Medical University & Shandong Academy of Medical SciencesShandong First Medical University & Shandong Academy of Medical SciencesShandong First Medical University & Shandong Academy of Medical SciencesDepartment of Clinical Laboratory MedicineMedical Research CenterSirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. In addition, SIRT2, as the only sirtuin protein colocalized with tubulin in the cytoplasm, has its own functions and characteristics. In recent years, studies have increasingly shown that SIRT2 can participate in the regulation of gene expression and regulate signal transduction in the metabolic pathway mainly through its post-translational modification of target genes; thus, SIRT2 has become a key centre in the metabolic pathway and participates in the pathological process of metabolic disorder-related diseases. In this paper, it is discussed that SIRT2 can regulate all aspects of gene expression, including epigenetic modification, replication, transcription and translation, and post-translational modification, which enables SIRT2 to participate in energy metabolism in life activities, and it is clarified that SIRT2 is involved in metabolic process-specific signal transduction mechanisms. Therefore, SIRT2 can be involved in metabolic disorder-related inflammation and oxidative stress, thereby triggering the occurrence of metabolic disorder-related diseases, such as neurodegenerative diseases, tumours, diabetes, and cardiovascular diseases. Currently, although the role of SIRT2 in some diseases is still controversial, given the multiple roles of SIRT2 in regulating physiological and pathological signal transduction, SIRT2 has become a key target for disease treatment. It is believed that with increasing research, the clinical application of SIRT2 will be promoted.http://dx.doi.org/10.1155/2022/9282484 |
| spellingShingle | Changhui Zhu Xue Dong Xiwei Wang Yingying Zheng Juanjuan Qiu Yanling Peng Jiajun Xu Zhengbin Chai Chunyan Liu Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction Genetics Research |
| title | Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction |
| title_full | Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction |
| title_fullStr | Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction |
| title_full_unstemmed | Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction |
| title_short | Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction |
| title_sort | multiple roles of sirt2 in regulating physiological and pathological signal transduction |
| url | http://dx.doi.org/10.1155/2022/9282484 |
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