Exploring the anticancer potential of nitrated N-substituted-4-hydroxy-2-quinolone-3-carboxamides: synthesis, biological assessment, and computational analysis

Exploring the anticancer potential of nitrated N-substituted-4-hydroxy-2-quinolone-3-carboxamides: synthesis, biological assessment, and computational analysis

Abstract Cancer remains the second leading cause of mortality globally, necessitating the development of novel therapeutic agents. In this work, we synthesized 34 derivatives of nitrated N-substituted-4-hydroxy-2-quinolone-3-carboxamides, which were spectroscopically analyzed using FT-IR, NMR (1H an...

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Bibliographic Details
Main Authors: Reem A. Islim, Nisreen S. Hamadeh, Reema Abu Khalaf, Rima Hajjo, Sanaa K. Bardaweel, Kamal Sweidan, Aya M. Al-Zuheiri, Swapnaa Balaji, Amit K. Tiwari, Ghassan Abushaikha, Dima A. Sabbah
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Chemistry
Subjects:
Anticancer agents
Cheminformatics
HCT-116
PC-3
Pathway analysis
Nitrated N-benzyl-4-hydroxy-2-quinolone-3-carboxamides
Online Access:https://doi.org/10.1186/s13065-025-01616-w
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https://doi.org/10.1186/s13065-025-01616-w

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