Comment on “A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children”
Abstract This comment critiques a trial comparing intranasal dexmedetomidine (DEX) and esketamine (sKET) for pediatric procedural sedation. Despite a large effect size, the small sample (n = 29) likely caused false-negative results (p = 0.09), necessitating larger trials. Safety concerns (e.g., aspi...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine |
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| Online Access: | https://doi.org/10.1186/s13049-025-01403-5 |
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| _version_ | 1849309751476748288 |
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| author | Jiajing Wang |
| author_facet | Jiajing Wang |
| author_sort | Jiajing Wang |
| collection | DOAJ |
| description | Abstract This comment critiques a trial comparing intranasal dexmedetomidine (DEX) and esketamine (sKET) for pediatric procedural sedation. Despite a large effect size, the small sample (n = 29) likely caused false-negative results (p = 0.09), necessitating larger trials. Safety concerns (e.g., aspiration risk), unaddressed long-term psychological outcomes, and limited pharmacokinetic data (delayed DEX onset, prolonged duration) challenge clinical applicability. Future studies should integrate objective measures and long-term follow-up. |
| format | Article |
| id | doaj-art-b4177fb164e14aebbb56fbf7be5b622d |
| institution | Kabale University |
| issn | 1757-7241 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine |
| spelling | doaj-art-b4177fb164e14aebbb56fbf7be5b622d2025-08-20T03:53:58ZengBMCScandinavian Journal of Trauma, Resuscitation and Emergency Medicine1757-72412025-05-013311310.1186/s13049-025-01403-5Comment on “A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children”Jiajing Wang0Department of Anesthesiology, Nanfang Hospital, Southern Medical University, The key Laboratory of Precision Anesthesia & perioperative Organ ProtectionAbstract This comment critiques a trial comparing intranasal dexmedetomidine (DEX) and esketamine (sKET) for pediatric procedural sedation. Despite a large effect size, the small sample (n = 29) likely caused false-negative results (p = 0.09), necessitating larger trials. Safety concerns (e.g., aspiration risk), unaddressed long-term psychological outcomes, and limited pharmacokinetic data (delayed DEX onset, prolonged duration) challenge clinical applicability. Future studies should integrate objective measures and long-term follow-up.https://doi.org/10.1186/s13049-025-01403-5DexmedetomidineEsketamineChildrenSample sizeSedation |
| spellingShingle | Jiajing Wang Comment on “A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children” Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine Dexmedetomidine Esketamine Children Sample size Sedation |
| title | Comment on “A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children” |
| title_full | Comment on “A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children” |
| title_fullStr | Comment on “A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children” |
| title_full_unstemmed | Comment on “A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children” |
| title_short | Comment on “A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children” |
| title_sort | comment on a randomized double blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children |
| topic | Dexmedetomidine Esketamine Children Sample size Sedation |
| url | https://doi.org/10.1186/s13049-025-01403-5 |
| work_keys_str_mv | AT jiajingwang commentonarandomizeddoubleblindtrialofintranasaldexmedetomidineversusintranasalesketamineforproceduralsedationandanalgesiainyoungchildren |