Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims
Background: Modern aggressive oncological treatment options for oral squamous cell carcinoma (OSCC) are inevitably associated with impaired general health-related quality of life (HRQoL) and oral HRQoL (OHRQoL). However, there is dire need for prospective and concomitant assessment of HRQoL and OHRQ...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221242682100004X |
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| author | Shailesh M. Gondivkar Amol R. Gadbail Sachin C. Sarode Amol Hedaoo Subhrajit Dasgupta Balkrishna Sharma Aparna Sharma Rima S. Gondivkar Monal Yuwanati Shankargouda Patil Rahul N. Gaikwad |
| author_facet | Shailesh M. Gondivkar Amol R. Gadbail Sachin C. Sarode Amol Hedaoo Subhrajit Dasgupta Balkrishna Sharma Aparna Sharma Rima S. Gondivkar Monal Yuwanati Shankargouda Patil Rahul N. Gaikwad |
| author_sort | Shailesh M. Gondivkar |
| collection | DOAJ |
| description | Background: Modern aggressive oncological treatment options for oral squamous cell carcinoma (OSCC) are inevitably associated with impaired general health-related quality of life (HRQoL) and oral HRQoL (OHRQoL). However, there is dire need for prospective and concomitant assessment of HRQoL and OHRQoL after different treatment regims. Hence, present study was designed to investigate HRQoL and OHRQoL in patients treated for OSCC using various modalities. Methods: 135 OSCC patients were grouped according to treatment rendered into Group A: surgery only; Group B: post-surgical radiotherapy (PRT); and Group C: post-surgical chemo-radiation (PCRT). The 12-item Short Form Health Survey (SF-12) and Oral Health Impact Profile-14 (OHIP-14) were intervened to assess HRQoL and OHRQoL respectively at 1-month and 6-months post-treatment. Results: At 1-month post-treatment, patients who received PCRT showed significantly lower mean values for physical and mental domains of SF-12 and higher mean subscales and overall OHIP-14 (24.57 ± 2.62) score than those treated by surgery alone (10.55 ± 2.26) and PRT (20.20 ± 3.80), with largest differences between PCRT and surgery alone groups (p < 0.001). Social functioning, general health and bodily pain of SF-12 and functional limitations, physical pain and physical disability amongst OHIP-14 domains were greatly affected. Although few physical domains of SF-12 showed significant improvement, mental domains remained a greater problem after 6 months. However, OHRQoL was significantly poor in all the three study groups (p < 0.001). Conclusion: Irrespective of the post-treatment duration, patients who received PCRT had worse HRQoL and OHRQoL. There is a need to identify factors associated with impaired HRQoL and OHRQoL to customize better therapeutic decisions. |
| format | Article |
| id | doaj-art-b40d7ba131fb42039d21d811c4cea5a2 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-b40d7ba131fb42039d21d811c4cea5a22024-11-23T06:28:36ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682021-04-01112125131Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regimsShailesh M. Gondivkar0Amol R. Gadbail1Sachin C. Sarode2Amol Hedaoo3Subhrajit Dasgupta4Balkrishna Sharma5Aparna Sharma6Rima S. Gondivkar7Monal Yuwanati8Shankargouda Patil9Rahul N. Gaikwad10Department of Oral Medicine & Radiology, Government Dental College & Hospital, Nagpur, Maharashtra, India; Corresponding author. Department of Oral Medicine & Radiology, Government Dental College & Hospital, Medical College Campus, Medical Square, Nagpur, Maharashtra State, India.Department of Dentistry, Indira Gandhi Government Medical College & Hospital, Nagpur, Maharashtra State, IndiaDepartment of Oral Pathology & Microbiology, Dr. D.Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra State, IndiaRST Cancer Hospital & Research Centre (Tertiary Care Cancer Centre), Nagpur, Maharashtra State, IndiaRST Cancer Hospital & Research Centre (Tertiary Care Cancer Centre), Nagpur, Maharashtra State, IndiaRST Cancer Hospital & Research Centre (Tertiary Care Cancer Centre), Nagpur, Maharashtra State, IndiaDepartment of Dentistry, Government Medical College & Hospital, Nagpur, Maharashtra State, India# 301, Aarti Regency, Mahalakshmi Nagar, Manewada Road, Nagpur, Maharashtra State, IndiaDepartment of Oral Pathology & Microbiology, People’s College of Dental Sciences & Research Centre, People’s University, Bhopal, Madhya Pradesh, IndiaDepartment of Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi ArabiaDepartment of Community Dentistry and Oral Epidemiology, College of Dentistry, Qassim University, Buraydah, Saudi ArabiaBackground: Modern aggressive oncological treatment options for oral squamous cell carcinoma (OSCC) are inevitably associated with impaired general health-related quality of life (HRQoL) and oral HRQoL (OHRQoL). However, there is dire need for prospective and concomitant assessment of HRQoL and OHRQoL after different treatment regims. Hence, present study was designed to investigate HRQoL and OHRQoL in patients treated for OSCC using various modalities. Methods: 135 OSCC patients were grouped according to treatment rendered into Group A: surgery only; Group B: post-surgical radiotherapy (PRT); and Group C: post-surgical chemo-radiation (PCRT). The 12-item Short Form Health Survey (SF-12) and Oral Health Impact Profile-14 (OHIP-14) were intervened to assess HRQoL and OHRQoL respectively at 1-month and 6-months post-treatment. Results: At 1-month post-treatment, patients who received PCRT showed significantly lower mean values for physical and mental domains of SF-12 and higher mean subscales and overall OHIP-14 (24.57 ± 2.62) score than those treated by surgery alone (10.55 ± 2.26) and PRT (20.20 ± 3.80), with largest differences between PCRT and surgery alone groups (p < 0.001). Social functioning, general health and bodily pain of SF-12 and functional limitations, physical pain and physical disability amongst OHIP-14 domains were greatly affected. Although few physical domains of SF-12 showed significant improvement, mental domains remained a greater problem after 6 months. However, OHRQoL was significantly poor in all the three study groups (p < 0.001). Conclusion: Irrespective of the post-treatment duration, patients who received PCRT had worse HRQoL and OHRQoL. There is a need to identify factors associated with impaired HRQoL and OHRQoL to customize better therapeutic decisions.http://www.sciencedirect.com/science/article/pii/S221242682100004XOral cancerQuality of lifeOral health-related quality of lifeOHIP-14SF-12 |
| spellingShingle | Shailesh M. Gondivkar Amol R. Gadbail Sachin C. Sarode Amol Hedaoo Subhrajit Dasgupta Balkrishna Sharma Aparna Sharma Rima S. Gondivkar Monal Yuwanati Shankargouda Patil Rahul N. Gaikwad Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims Journal of Oral Biology and Craniofacial Research Oral cancer Quality of life Oral health-related quality of life OHIP-14 SF-12 |
| title | Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims |
| title_full | Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims |
| title_fullStr | Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims |
| title_full_unstemmed | Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims |
| title_short | Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims |
| title_sort | oral and general health related quality of life in oral squamous cell carcinoma patients comparative analysis of different treatment regims |
| topic | Oral cancer Quality of life Oral health-related quality of life OHIP-14 SF-12 |
| url | http://www.sciencedirect.com/science/article/pii/S221242682100004X |
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