Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities
Abstract Plasmodium vivax, a challenging species to eliminate, causes millions of malaria cases globally annually. Developing an effective vaccine is crucial in the fight against vivax malaria, but considering the limited number of studies focusing on the identification and development of P. vivax-s...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-72671-x |
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| author | Isabela Ferreira Soares Barbara de Oliveira Baptista Ada da Silva Matos Rodrigo Nunes Rodrigues-da-Silva Mario Antonio Kujbida Junior Letusa Albrecht Cinthia Magalhães Rodolphi Kézia Katiani Gorza Scopel Ana Luiza Carneiro Alencar Rodrigo Medeiros de Souza Hugo Amorim dos Santos de Souza Evelyn Kety Pratt Riccio Jenifer Peixoto de Barros Paulo Renato Rivas Totino Cláudio Tadeu Daniel-Ribeiro Lilian Rose Pratt-Riccio Josué da Costa Lima-Junior |
| author_facet | Isabela Ferreira Soares Barbara de Oliveira Baptista Ada da Silva Matos Rodrigo Nunes Rodrigues-da-Silva Mario Antonio Kujbida Junior Letusa Albrecht Cinthia Magalhães Rodolphi Kézia Katiani Gorza Scopel Ana Luiza Carneiro Alencar Rodrigo Medeiros de Souza Hugo Amorim dos Santos de Souza Evelyn Kety Pratt Riccio Jenifer Peixoto de Barros Paulo Renato Rivas Totino Cláudio Tadeu Daniel-Ribeiro Lilian Rose Pratt-Riccio Josué da Costa Lima-Junior |
| author_sort | Isabela Ferreira Soares |
| collection | DOAJ |
| description | Abstract Plasmodium vivax, a challenging species to eliminate, causes millions of malaria cases globally annually. Developing an effective vaccine is crucial in the fight against vivax malaria, but considering the limited number of studies focusing on the identification and development of P. vivax-specific vaccine candidates, exploring new antigens is an urgent need. The merozoite protein CyRPA is essential for P. falciparum growth and erythrocyte invasion and corresponds to a promising candidate antigen. In P. vivax, a single study with multiple vaccine candidates indicates PvCyRPA with strong association with protection, outperforming classic malaria vaccine candidates. However, little is known about the specific naturally acquired response in the Americas, as well as the antigen epitope mapping. For this reason, we aimed to investigate the cellular and humoral immune response elicited against PvCyRPA in Brazilian endemic areas to identify the existence of immunodominant regions and the potential of this protein as a single or even a multi-stage specific malaria vaccine candidate for P. vivax. The results demonstrated that PvCyRPA is naturally immunogenic in Brazilian Amazon individuals previously exposed to malaria, which presented anti-PvCyRPA cytophilic antibodies. Moreover, our data show that the protein also possesses important immunogenic regions with an overlap of B and T cell epitopes. These data reinforce the possibility of including PvCyRPA in vaccine formulations for P. vivax. |
| format | Article |
| id | doaj-art-b3fed18cfcb24b098ea6e8ea3f37900c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-b3fed18cfcb24b098ea6e8ea3f37900c2024-11-10T12:22:25ZengNature PortfolioScientific Reports2045-23222024-11-0114111510.1038/s41598-024-72671-xCharacterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communitiesIsabela Ferreira Soares0Barbara de Oliveira Baptista1Ada da Silva Matos2Rodrigo Nunes Rodrigues-da-Silva3Mario Antonio Kujbida Junior4Letusa Albrecht5Cinthia Magalhães Rodolphi6Kézia Katiani Gorza Scopel7Ana Luiza Carneiro Alencar8Rodrigo Medeiros de Souza9Hugo Amorim dos Santos de Souza10Evelyn Kety Pratt Riccio11Jenifer Peixoto de Barros12Paulo Renato Rivas Totino13Cláudio Tadeu Daniel-Ribeiro14Lilian Rose Pratt-Riccio15Josué da Costa Lima-Junior16Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, (Fiocruz)Laboratório de Pesquisa em Malária, IOC, FiocruzLaboratório de Imunoparasitologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, (Fiocruz)Laboratório de Hantaviroses e Rickettsioses, IOC, FiocruzLaboratório de Pesquisa em Apicomplexa, Instituto Carlos Chagas, FiocruzLaboratório de Pesquisa em Apicomplexa, Instituto Carlos Chagas, FiocruzNúcleo de Pesquisa em Parasitologia, Universidade Federal de Juiz de ForaNúcleo de Pesquisa em Parasitologia, Universidade Federal de Juiz de ForaLaboratório de Imunoparasitologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, (Fiocruz)Laboratório de Doenças infecciosas na Amazônia Ocidental - Universidade Federal do AcreLaboratório de Pesquisa em Malária, IOC, FiocruzLaboratório de Pesquisa em Malária, IOC, FiocruzLaboratório de Pesquisa em Malária, IOC, FiocruzLaboratório de Pesquisa em Malária, IOC, FiocruzLaboratório de Pesquisa em Malária, IOC, FiocruzLaboratório de Pesquisa em Malária, IOC, FiocruzLaboratório de Imunoparasitologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, (Fiocruz)Abstract Plasmodium vivax, a challenging species to eliminate, causes millions of malaria cases globally annually. Developing an effective vaccine is crucial in the fight against vivax malaria, but considering the limited number of studies focusing on the identification and development of P. vivax-specific vaccine candidates, exploring new antigens is an urgent need. The merozoite protein CyRPA is essential for P. falciparum growth and erythrocyte invasion and corresponds to a promising candidate antigen. In P. vivax, a single study with multiple vaccine candidates indicates PvCyRPA with strong association with protection, outperforming classic malaria vaccine candidates. However, little is known about the specific naturally acquired response in the Americas, as well as the antigen epitope mapping. For this reason, we aimed to investigate the cellular and humoral immune response elicited against PvCyRPA in Brazilian endemic areas to identify the existence of immunodominant regions and the potential of this protein as a single or even a multi-stage specific malaria vaccine candidate for P. vivax. The results demonstrated that PvCyRPA is naturally immunogenic in Brazilian Amazon individuals previously exposed to malaria, which presented anti-PvCyRPA cytophilic antibodies. Moreover, our data show that the protein also possesses important immunogenic regions with an overlap of B and T cell epitopes. These data reinforce the possibility of including PvCyRPA in vaccine formulations for P. vivax.https://doi.org/10.1038/s41598-024-72671-x |
| spellingShingle | Isabela Ferreira Soares Barbara de Oliveira Baptista Ada da Silva Matos Rodrigo Nunes Rodrigues-da-Silva Mario Antonio Kujbida Junior Letusa Albrecht Cinthia Magalhães Rodolphi Kézia Katiani Gorza Scopel Ana Luiza Carneiro Alencar Rodrigo Medeiros de Souza Hugo Amorim dos Santos de Souza Evelyn Kety Pratt Riccio Jenifer Peixoto de Barros Paulo Renato Rivas Totino Cláudio Tadeu Daniel-Ribeiro Lilian Rose Pratt-Riccio Josué da Costa Lima-Junior Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities Scientific Reports |
| title | Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities |
| title_full | Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities |
| title_fullStr | Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities |
| title_full_unstemmed | Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities |
| title_short | Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities |
| title_sort | characterization of t and b cell epitopes in pvcyrpa by studying the naturally acquired immune response in brazilian amazon communities |
| url | https://doi.org/10.1038/s41598-024-72671-x |
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