An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maize
Farmers in North America face significant pressure from insects in their maize fields, particularly from corn rootworm (Diabrotica spp.). Research into proteins capable of insecticidal activity has found several produced by ferns. One protein, IPD079Ea, was derived from Ophioglossum pendulum and has...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | GM Crops & Food |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645698.2023.2299503 |
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| author | Bridget F. O’Neill Chad Boeckman Kristine LeRoy Chris Linderblood Taylor Olson Rachel Woods Mary Challender |
| author_facet | Bridget F. O’Neill Chad Boeckman Kristine LeRoy Chris Linderblood Taylor Olson Rachel Woods Mary Challender |
| author_sort | Bridget F. O’Neill |
| collection | DOAJ |
| description | Farmers in North America face significant pressure from insects in their maize fields, particularly from corn rootworm (Diabrotica spp.). Research into proteins capable of insecticidal activity has found several produced by ferns. One protein, IPD079Ea, was derived from Ophioglossum pendulum and has shown activity against corn rootworm. An environmental risk assessment was conducted for maize event DP-915635-4, which provides control of corn rootworms via expression of the IPD079Ea protein. This assessment focused on IPD079Ea and characterized potential exposure and hazard to non-target organisms (NTOs). For exposure, estimated environmental concentrations (EECs) were calculated. For hazard, laboratory dietary toxicity studies were conducted with IPD079Ea and surrogate non-target organisms. Environmental risk was characterized by comparing hazard and exposure to calculate the margin of exposure (MOE). Based on the MOE values for DP-915635-4 maize, the IPD079Ea protein is not expected to result in unreasonable adverse effects on beneficial NTO populations at environmentally relevant concentrations. |
| format | Article |
| id | doaj-art-b3ea96a62fc944878b5290a0045150f2 |
| institution | Kabale University |
| issn | 2164-5698 2164-5701 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | GM Crops & Food |
| spelling | doaj-art-b3ea96a62fc944878b5290a0045150f22024-12-16T16:41:27ZengTaylor & Francis GroupGM Crops & Food2164-56982164-57012024-12-01151153110.1080/21645698.2023.2299503An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maizeBridget F. O’Neill0Chad Boeckman1Kristine LeRoy2Chris Linderblood3Taylor Olson4Rachel Woods5Mary Challender6Corteva Agriscience™, Regulatory and Stewardship institution, Indianapolis, IN, USACorteva Agriscience™, Regulatory and Stewardship, Johnston, IA, USACorteva Agriscience™, Regulatory and Stewardship, Johnston, IA, USACorteva Agriscience™, Regulatory and Stewardship, Johnston, IA, USACorteva Agriscience™, Regulatory and Stewardship, Johnston, IA, USACorteva Agriscience™, Regulatory and Stewardship, Johnston, IA, USACorteva Agriscience™, Regulatory and Stewardship, Johnston, IA, USAFarmers in North America face significant pressure from insects in their maize fields, particularly from corn rootworm (Diabrotica spp.). Research into proteins capable of insecticidal activity has found several produced by ferns. One protein, IPD079Ea, was derived from Ophioglossum pendulum and has shown activity against corn rootworm. An environmental risk assessment was conducted for maize event DP-915635-4, which provides control of corn rootworms via expression of the IPD079Ea protein. This assessment focused on IPD079Ea and characterized potential exposure and hazard to non-target organisms (NTOs). For exposure, estimated environmental concentrations (EECs) were calculated. For hazard, laboratory dietary toxicity studies were conducted with IPD079Ea and surrogate non-target organisms. Environmental risk was characterized by comparing hazard and exposure to calculate the margin of exposure (MOE). Based on the MOE values for DP-915635-4 maize, the IPD079Ea protein is not expected to result in unreasonable adverse effects on beneficial NTO populations at environmentally relevant concentrations.https://www.tandfonline.com/doi/10.1080/21645698.2023.2299503DP-915635-4 maizegenetically modifiedIPD079Ea proteinnon-target organismsafety assessmentzea mays L |
| spellingShingle | Bridget F. O’Neill Chad Boeckman Kristine LeRoy Chris Linderblood Taylor Olson Rachel Woods Mary Challender An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maize GM Crops & Food DP-915635-4 maize genetically modified IPD079Ea protein non-target organism safety assessment zea mays L |
| title | An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maize |
| title_full | An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maize |
| title_fullStr | An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maize |
| title_full_unstemmed | An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maize |
| title_short | An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maize |
| title_sort | environmental risk assessment of ipd079ea a protein derived from ophioglossum pendulum with activity against diabrotica spp in maize |
| topic | DP-915635-4 maize genetically modified IPD079Ea protein non-target organism safety assessment zea mays L |
| url | https://www.tandfonline.com/doi/10.1080/21645698.2023.2299503 |
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