Evaluating the Role of Hyperbaric Oxygen Therapy in Enhancing Skin Graft Outcomes: Mechanisms, Clinical Evidence, and Comparative Efficacy

Skin grafting is a critical procedure for treating skin defects from burns, trauma, and surgical interventions, yet complications such as ischemia, necrosis, and infection can limit graft success. Hyperbaric Oxygen Therapy (HBOT) has emerged as a promising adjunctive treatment that enhances skin gra...

Full description

Saved in:
Bibliographic Details
Main Authors: Omer A. Idris, Alexandra L. Uridge, Syann Hollins, Kyle Ver Steeg
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Oxygen
Subjects:
Online Access:https://www.mdpi.com/2673-9801/4/4/23
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1846103308963414016
author Omer A. Idris
Alexandra L. Uridge
Syann Hollins
Kyle Ver Steeg
author_facet Omer A. Idris
Alexandra L. Uridge
Syann Hollins
Kyle Ver Steeg
author_sort Omer A. Idris
collection DOAJ
description Skin grafting is a critical procedure for treating skin defects from burns, trauma, and surgical interventions, yet complications such as ischemia, necrosis, and infection can limit graft success. Hyperbaric Oxygen Therapy (HBOT) has emerged as a promising adjunctive treatment that enhances skin graft viability through mechanisms including enhanced oxygenation, angiogenesis, reduced inflammation, and anti-infective effects. This review synthesizes findings from clinical studies, comparative analyses, and case reports to clarify HBOT’s efficacy in improving skin graft outcomes. Methods include a comprehensive analysis of HBOT’s impact on graft take rates, healing times, and complication rates. Results indicate that HBOT significantly improves graft survival by mitigating ischemia and infection, while comparative studies show a reduction in major amputations and improved healing in complex cases, such as diabetic foot ulcers and traumatic injuries. These findings suggest that HBOT can serve as a valuable adjunct to standard grafting procedures, offering a multifaceted approach to improve graft viability, especially in high-risk cases. This review highlights HBOT’s potential for integration into wound management protocols, providing a foundation for further exploration into its efficacy and applications in reconstructive surgery.
format Article
id doaj-art-b3d3d25ceb6d4b40b31fb329afb01a43
institution Kabale University
issn 2673-9801
language English
publishDate 2024-10-01
publisher MDPI AG
record_format Article
series Oxygen
spelling doaj-art-b3d3d25ceb6d4b40b31fb329afb01a432024-12-27T14:45:02ZengMDPI AGOxygen2673-98012024-10-014437738810.3390/oxygen4040023Evaluating the Role of Hyperbaric Oxygen Therapy in Enhancing Skin Graft Outcomes: Mechanisms, Clinical Evidence, and Comparative EfficacyOmer A. Idris0Alexandra L. Uridge1Syann Hollins2Kyle Ver Steeg3Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008, USADepartment of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008, USADepartment of Psychology, DePaul University, Chicago, IL 60614, USABronson Methodist Hospital Plastic Surgery Specialists, Portage, MI 49024, USASkin grafting is a critical procedure for treating skin defects from burns, trauma, and surgical interventions, yet complications such as ischemia, necrosis, and infection can limit graft success. Hyperbaric Oxygen Therapy (HBOT) has emerged as a promising adjunctive treatment that enhances skin graft viability through mechanisms including enhanced oxygenation, angiogenesis, reduced inflammation, and anti-infective effects. This review synthesizes findings from clinical studies, comparative analyses, and case reports to clarify HBOT’s efficacy in improving skin graft outcomes. Methods include a comprehensive analysis of HBOT’s impact on graft take rates, healing times, and complication rates. Results indicate that HBOT significantly improves graft survival by mitigating ischemia and infection, while comparative studies show a reduction in major amputations and improved healing in complex cases, such as diabetic foot ulcers and traumatic injuries. These findings suggest that HBOT can serve as a valuable adjunct to standard grafting procedures, offering a multifaceted approach to improve graft viability, especially in high-risk cases. This review highlights HBOT’s potential for integration into wound management protocols, providing a foundation for further exploration into its efficacy and applications in reconstructive surgery.https://www.mdpi.com/2673-9801/4/4/23skin graftingHyperbaric Oxygen TherapyHBOTwound healingangiogenesisischemia
spellingShingle Omer A. Idris
Alexandra L. Uridge
Syann Hollins
Kyle Ver Steeg
Evaluating the Role of Hyperbaric Oxygen Therapy in Enhancing Skin Graft Outcomes: Mechanisms, Clinical Evidence, and Comparative Efficacy
Oxygen
skin grafting
Hyperbaric Oxygen Therapy
HBOT
wound healing
angiogenesis
ischemia
title Evaluating the Role of Hyperbaric Oxygen Therapy in Enhancing Skin Graft Outcomes: Mechanisms, Clinical Evidence, and Comparative Efficacy
title_full Evaluating the Role of Hyperbaric Oxygen Therapy in Enhancing Skin Graft Outcomes: Mechanisms, Clinical Evidence, and Comparative Efficacy
title_fullStr Evaluating the Role of Hyperbaric Oxygen Therapy in Enhancing Skin Graft Outcomes: Mechanisms, Clinical Evidence, and Comparative Efficacy
title_full_unstemmed Evaluating the Role of Hyperbaric Oxygen Therapy in Enhancing Skin Graft Outcomes: Mechanisms, Clinical Evidence, and Comparative Efficacy
title_short Evaluating the Role of Hyperbaric Oxygen Therapy in Enhancing Skin Graft Outcomes: Mechanisms, Clinical Evidence, and Comparative Efficacy
title_sort evaluating the role of hyperbaric oxygen therapy in enhancing skin graft outcomes mechanisms clinical evidence and comparative efficacy
topic skin grafting
Hyperbaric Oxygen Therapy
HBOT
wound healing
angiogenesis
ischemia
url https://www.mdpi.com/2673-9801/4/4/23
work_keys_str_mv AT omeraidris evaluatingtheroleofhyperbaricoxygentherapyinenhancingskingraftoutcomesmechanismsclinicalevidenceandcomparativeefficacy
AT alexandraluridge evaluatingtheroleofhyperbaricoxygentherapyinenhancingskingraftoutcomesmechanismsclinicalevidenceandcomparativeefficacy
AT syannhollins evaluatingtheroleofhyperbaricoxygentherapyinenhancingskingraftoutcomesmechanismsclinicalevidenceandcomparativeefficacy
AT kyleversteeg evaluatingtheroleofhyperbaricoxygentherapyinenhancingskingraftoutcomesmechanismsclinicalevidenceandcomparativeefficacy