Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers
Purpose To analyze the current practice of regional hyperthermia (RHT) for soft tissue sarcoma (STS) at 12 European centers to provide an overview, find consensuses and identify controversies necessary for future guidelines and clinical trials.Methods In this cross-sectional survey study, a 27-item...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2342348 |
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| author | Siyer Roohani Felix Ehret Marcus Beck Danai P. Veltsista Jacek Nadobny Sebastian Zschaeck Sultan Abdel-Rahman Franziska Eckert Anne Flörcken Rolf D. Issels Stephan Klöck Robert Krempien Lars H. Lindner Markus Notter Oliver J. Ott Daniel Pink Vlatko Potkrajcic Peter Reichardt Oliver Riesterer Mateusz Jacek Spałek Emanuel Stutz Rüdiger Wessalowski Thomas Zilli Daniel Zips Pirus Ghadjar David Kaul |
| author_facet | Siyer Roohani Felix Ehret Marcus Beck Danai P. Veltsista Jacek Nadobny Sebastian Zschaeck Sultan Abdel-Rahman Franziska Eckert Anne Flörcken Rolf D. Issels Stephan Klöck Robert Krempien Lars H. Lindner Markus Notter Oliver J. Ott Daniel Pink Vlatko Potkrajcic Peter Reichardt Oliver Riesterer Mateusz Jacek Spałek Emanuel Stutz Rüdiger Wessalowski Thomas Zilli Daniel Zips Pirus Ghadjar David Kaul |
| author_sort | Siyer Roohani |
| collection | DOAJ |
| description | Purpose To analyze the current practice of regional hyperthermia (RHT) for soft tissue sarcoma (STS) at 12 European centers to provide an overview, find consensuses and identify controversies necessary for future guidelines and clinical trials.Methods In this cross-sectional survey study, a 27-item questionnaire assessing clinical subjects and procedural details on RHT for STS was distributed to 12 European cancer centers for RHT.Results We have identified seven controversies and five consensus points. Of 12 centers, 6 offer both, RHT with chemotherapy (CTX) or with radiotherapy (RT). Two centers only offer RHT with CTX and four centers only offer RHT with RT. All 12 centers apply RHT for localized, high-risk STS of the extremities, trunk wall and retroperitoneum. However, eight centers also use RHT in metastatic STS, five in palliative STS, eight for superficial STS and six for low-grade STS. Pretherapeutic imaging for RHT treatment planning is used by 10 centers, 9 centers set 40–43 °C as the intratumoral target temperature, and all centers use skin detectors or probes in body orifices for thermometry.Discussion There is disagreement regarding the integration of RHT in contemporary interdisciplinary care of STS patients. Many clinical controversies exist that require a standardized consensus guideline and innovative study ideas. At the same time, our data has shown that existing guidelines and decades of experience with the technique of RHT have mostly standardized procedural aspects.Conclusions The provided results may serve as a basis for future guidelines and inform future clinical trials for RHT in STS patients. |
| format | Article |
| id | doaj-art-b3cc981ec33c43e197880a104e7f15f2 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | International Journal of Hyperthermia |
| spelling | doaj-art-b3cc981ec33c43e197880a104e7f15f22025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2342348Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centersSiyer Roohani0Felix Ehret1Marcus Beck2Danai P. Veltsista3Jacek Nadobny4Sebastian Zschaeck5Sultan Abdel-Rahman6Franziska Eckert7Anne Flörcken8Rolf D. Issels9Stephan Klöck10Robert Krempien11Lars H. Lindner12Markus Notter13Oliver J. Ott14Daniel Pink15Vlatko Potkrajcic16Peter Reichardt17Oliver Riesterer18Mateusz Jacek Spałek19Emanuel Stutz20Rüdiger Wessalowski21Thomas Zilli22Daniel Zips23Pirus Ghadjar24David Kaul25Department of Radiation Oncology, Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of Radiation Oncology, University Hospital Tübingen, Tübingen, GermanyCharité − Universitätsmedizin Berlin, Berlin, GermanyDepartment of Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of Radiation Oncology, Lindenhofspital Bern, Bern, SwitzerlandClinic for Radiotherapy, HELIOS Klinikum Berlin-Buch, Berlin, GermanyDepartment of Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of Radiation Oncology, Lindenhofspital Bern, Bern, SwitzerlandDepartment of Radiation Oncology, Universitätsklinikum Erlangen, Erlangen, GermanyDepartment of Medical Oncology, Helios Klinikum Bad Saarow, Bad Saarow, GermanyDepartment of Radiation Oncology, University Hospital Tübingen, Tübingen, GermanyDepartment of Medical Oncology, Helios Klinikum Berlin-Buch, and Medical School Berlin, Berlin, GermanyCenter for Radiation Oncology KSA-KSB, Kantonsspital Aarau, Aarau, SwitzerlandDepartment of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, PolandDepartment of Radiation Oncology, Inselspital Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Paediatric Haematology and Oncology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, GermanyDepartment of Radiation Oncology, Oncology Institute of Southern Switzerland (IOSI), EOC, Bellinzona, SwitzerlandDepartment of Radiation Oncology, Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyPurpose To analyze the current practice of regional hyperthermia (RHT) for soft tissue sarcoma (STS) at 12 European centers to provide an overview, find consensuses and identify controversies necessary for future guidelines and clinical trials.Methods In this cross-sectional survey study, a 27-item questionnaire assessing clinical subjects and procedural details on RHT for STS was distributed to 12 European cancer centers for RHT.Results We have identified seven controversies and five consensus points. Of 12 centers, 6 offer both, RHT with chemotherapy (CTX) or with radiotherapy (RT). Two centers only offer RHT with CTX and four centers only offer RHT with RT. All 12 centers apply RHT for localized, high-risk STS of the extremities, trunk wall and retroperitoneum. However, eight centers also use RHT in metastatic STS, five in palliative STS, eight for superficial STS and six for low-grade STS. Pretherapeutic imaging for RHT treatment planning is used by 10 centers, 9 centers set 40–43 °C as the intratumoral target temperature, and all centers use skin detectors or probes in body orifices for thermometry.Discussion There is disagreement regarding the integration of RHT in contemporary interdisciplinary care of STS patients. Many clinical controversies exist that require a standardized consensus guideline and innovative study ideas. At the same time, our data has shown that existing guidelines and decades of experience with the technique of RHT have mostly standardized procedural aspects.Conclusions The provided results may serve as a basis for future guidelines and inform future clinical trials for RHT in STS patients.https://www.tandfonline.com/doi/10.1080/02656736.2024.2342348Hyperthermiasoft tissue sarcomaguidelinecontroversiesradiotherapy |
| spellingShingle | Siyer Roohani Felix Ehret Marcus Beck Danai P. Veltsista Jacek Nadobny Sebastian Zschaeck Sultan Abdel-Rahman Franziska Eckert Anne Flörcken Rolf D. Issels Stephan Klöck Robert Krempien Lars H. Lindner Markus Notter Oliver J. Ott Daniel Pink Vlatko Potkrajcic Peter Reichardt Oliver Riesterer Mateusz Jacek Spałek Emanuel Stutz Rüdiger Wessalowski Thomas Zilli Daniel Zips Pirus Ghadjar David Kaul Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers International Journal of Hyperthermia Hyperthermia soft tissue sarcoma guideline controversies radiotherapy |
| title | Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers |
| title_full | Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers |
| title_fullStr | Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers |
| title_full_unstemmed | Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers |
| title_short | Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers |
| title_sort | regional hyperthermia for soft tissue sarcoma a survey on current practice controversies and consensus among 12 european centers |
| topic | Hyperthermia soft tissue sarcoma guideline controversies radiotherapy |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2342348 |
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