5-Aminopyrazole Dimerization: Cu-Promoted Switchable Synthesis of Pyrazole-Fused Pyridazines and Pyrazines via Direct Coupling of C-H/N-H, C-H/C-H, and N-H/N-H Bonds

5-Aminopyrazole Dimerization: Cu-Promoted Switchable Synthesis of Pyrazole-Fused Pyridazines and Pyrazines via Direct Coupling of C-H/N-H, C-H/C-H, and N-H/N-H Bonds

A Cu-promoted highly chemoselective dimerization of 5-aminopyrazoles to produce pyrazole-fused pyridazines and pyrazines is reported. The protocol generates switchable products via the direct coupling of C-H/N-H, C-H/C-H and N-H/N-H bonds, with the merits of broad substrate scope and high functional...

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Main Authors: Yi-Xin Chai, Jun-Jie Ren, Yi-Ming Li, Yi-Cheng Bai, Qing-Qing Zhang, Yi-Zhen Zhao, Xue Yang, Xiao-Han Zhang, Xin-Shuang Zhang, An-Xin Wu, Yan-Ping Zhu, Yuan-Yuan Sun
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
Cu-promoted chemoselective dimerization
C-H/N-H, C-H/C-H, and N-H/N-H direct coupling
switchable products
fused pyridazines and pyrazines
Online Access:https://www.mdpi.com/1420-3049/30/2/381
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