Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts
Abstract Background Among hypertensive cohorts across different nations, the relationship between the triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence and mortality remains to be elucidated. Methods This study enrolled 9,...
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2025-01-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-024-02571-x |
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| author | Yanqiu Huang Yi Zhou Yadan Xu Xiaoyu Wang Ziyi Zhou Kang Wu Qiqi Meng Liao Wang Yang Yang Hong Gao Juan Ji Xu Jiang Yang Yang Lipeng Hao Hui Wang |
| author_facet | Yanqiu Huang Yi Zhou Yadan Xu Xiaoyu Wang Ziyi Zhou Kang Wu Qiqi Meng Liao Wang Yang Yang Hong Gao Juan Ji Xu Jiang Yang Yang Lipeng Hao Hui Wang |
| author_sort | Yanqiu Huang |
| collection | DOAJ |
| description | Abstract Background Among hypertensive cohorts across different nations, the relationship between the triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence and mortality remains to be elucidated. Methods This study enrolled 9,283, 164,357, and 5,334 hypertensives from the National Health and Nutrition Examination Survey (NHANES), UK Biobank (UKBB), and Shanghai Pudong cohort. The related outcomes for CVD were defined by multivariate Cox proportional hazards models, Generalized Additive Models and Mendelian randomization analysis. Mediation analysis explored the mediating role of inflammatory markers in the above relationships. Results Five measures of insulin resistance were linked to CVD and related death in a U-shaped pattern, with the highest group having different risk increases. Higher glucose triglyceride-waist height ratio (TyG-WHTR) was linked to higher all-cause mortality (UKBB: HR 1.21, 95%CI 1.16–1.26, NHANES: HR 1.17, 95%CI 1.00–1.36), CVD mortality (UKBB: HR 1.36, 95%CI 1.23–1.49, NHANES: HR 1.32, 95%CI 1.00–1.72) risks. In the China Pudong cohort, higher triglyceride/high-density lipoprotein-cholesterol (TG/HDL_C) ratio was associated with higher risks of CVD and stroke (HR 1.31, 95%CI 1.00–1.73 and 1.67, 1.06–2.63). Inflammation markers like systemic inflammatory response index (SIRI) and C-reactive protein (CRP) partially explained these links, with CRP having a stronger effect. Genetically predicted TyG was also linked to stroke (OR 1.26, 95%CI 1.10–1.45) risk. Conclusions An elevated TyG index and its related indices are significantly correlated with an increased risk of CVD and related mortality across three national cohorts. These indices are anticipated to serve as valid predictors of incident CVD and mortality in individuals with hypertension. Graphical abstract |
| format | Article |
| id | doaj-art-b38e2d2905d44ad78e042b1c017cb9a0 |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Cardiovascular Diabetology |
| spelling | doaj-art-b38e2d2905d44ad78e042b1c017cb9a02025-01-12T12:07:04ZengBMCCardiovascular Diabetology1475-28402025-01-0124111610.1186/s12933-024-02571-xInflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohortsYanqiu Huang0Yi Zhou1Yadan Xu2Xiaoyu Wang3Ziyi Zhou4Kang Wu5Qiqi Meng6Liao Wang7Yang Yang8Hong Gao9Juan Ji10Xu Jiang11Yang Yang12Lipeng Hao13Hui Wang14State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicinePudong New District Center for Disease Control and Prevention of ShanghaiState Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineDivision of Gastroenterology and Hepatology, NHC Key Laboratory of Digestive Diseases, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive DiseaseState Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicinePudong New District Center for Disease Control and Prevention of ShanghaiPudong New District Center for Disease Control and Prevention of ShanghaiShanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System, Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Jiao Tong University of Medicine Affiliated Ninth People’s HospitalBloomberg School of Public Health, Johns Hopkins UniversityCommunity Health Center of Huaqiao TownCommunity Health Center of Huaqiao TownShanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System, Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Jiao Tong University of Medicine Affiliated Ninth People’s HospitalState Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicinePudong New District Center for Disease Control and Prevention of ShanghaiState Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineAbstract Background Among hypertensive cohorts across different nations, the relationship between the triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence and mortality remains to be elucidated. Methods This study enrolled 9,283, 164,357, and 5,334 hypertensives from the National Health and Nutrition Examination Survey (NHANES), UK Biobank (UKBB), and Shanghai Pudong cohort. The related outcomes for CVD were defined by multivariate Cox proportional hazards models, Generalized Additive Models and Mendelian randomization analysis. Mediation analysis explored the mediating role of inflammatory markers in the above relationships. Results Five measures of insulin resistance were linked to CVD and related death in a U-shaped pattern, with the highest group having different risk increases. Higher glucose triglyceride-waist height ratio (TyG-WHTR) was linked to higher all-cause mortality (UKBB: HR 1.21, 95%CI 1.16–1.26, NHANES: HR 1.17, 95%CI 1.00–1.36), CVD mortality (UKBB: HR 1.36, 95%CI 1.23–1.49, NHANES: HR 1.32, 95%CI 1.00–1.72) risks. In the China Pudong cohort, higher triglyceride/high-density lipoprotein-cholesterol (TG/HDL_C) ratio was associated with higher risks of CVD and stroke (HR 1.31, 95%CI 1.00–1.73 and 1.67, 1.06–2.63). Inflammation markers like systemic inflammatory response index (SIRI) and C-reactive protein (CRP) partially explained these links, with CRP having a stronger effect. Genetically predicted TyG was also linked to stroke (OR 1.26, 95%CI 1.10–1.45) risk. Conclusions An elevated TyG index and its related indices are significantly correlated with an increased risk of CVD and related mortality across three national cohorts. These indices are anticipated to serve as valid predictors of incident CVD and mortality in individuals with hypertension. Graphical abstracthttps://doi.org/10.1186/s12933-024-02571-xTriglyceride-glucose indexObesity indicatorsTG/HDL_C ratioAdverse cardiovascular eventsMendelian randomizationInflammatory markers |
| spellingShingle | Yanqiu Huang Yi Zhou Yadan Xu Xiaoyu Wang Ziyi Zhou Kang Wu Qiqi Meng Liao Wang Yang Yang Hong Gao Juan Ji Xu Jiang Yang Yang Lipeng Hao Hui Wang Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts Cardiovascular Diabetology Triglyceride-glucose index Obesity indicators TG/HDL_C ratio Adverse cardiovascular events Mendelian randomization Inflammatory markers |
| title | Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts |
| title_full | Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts |
| title_fullStr | Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts |
| title_full_unstemmed | Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts |
| title_short | Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts |
| title_sort | inflammatory markers link triglyceride glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension insights from three cohorts |
| topic | Triglyceride-glucose index Obesity indicators TG/HDL_C ratio Adverse cardiovascular events Mendelian randomization Inflammatory markers |
| url | https://doi.org/10.1186/s12933-024-02571-x |
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