Total synthesis and biological evaluation of Koshidacin B, TAN-1746, and Ac-TAN-1746

Total synthesis and biological evaluation of Koshidacin B, TAN-1746, and Ac-TAN-1746

Abstract Analogues of chlamydocin derivatives consistently demonstrate multifaceted bioactivities, particularly through HDAC inhibition mechanisms, oncolytic efficacy, and neuronal preservation capacities. These activities primarily originate from their unique cyclic tetrapeptide scaffold and functi...

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Main Authors: Xiong-En Long, Hailiang Xing, Yixin He, Xuanli Meng, Yanling Ma, Chang Liu, Xi Cao, Huiru Nan, Min-Jing Cheng, Jia-Lei Yan, Junyang Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Chemistry
Subjects:
Total synthesis
Chlamydocin analog
Koshidacin B
TAN-1746
Cross metathesis
Online Access:https://doi.org/10.1186/s13065-025-01581-4
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