Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicin
This study reports the synthesis and characterization of a magnetic composite metal-organic framework, The Fe3O4@MIL-101-OH/Chitosan nanocomposite was used for the first time to adsorb and release the drug doxorubicin (DOX). The nanocomposite was characterized using scanning electron microscopy (SEM...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Polymer Testing |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0142941824003362 |
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| author | Iman Najafipour Nafiseh Emami Pegah Sadeh Adonis Amoli Sareh Mosleh-Shirazi Ali Mohammad Amani Hesam Kamyab Shreeshivadasan Chelliapan Seyed Reza Kasaee Ehsan Vafa |
| author_facet | Iman Najafipour Nafiseh Emami Pegah Sadeh Adonis Amoli Sareh Mosleh-Shirazi Ali Mohammad Amani Hesam Kamyab Shreeshivadasan Chelliapan Seyed Reza Kasaee Ehsan Vafa |
| author_sort | Iman Najafipour |
| collection | DOAJ |
| description | This study reports the synthesis and characterization of a magnetic composite metal-organic framework, The Fe3O4@MIL-101-OH/Chitosan nanocomposite was used for the first time to adsorb and release the drug doxorubicin (DOX). The nanocomposite was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM). The characterization results showed that the synthesized nanocomposite has a crystalline structure and good magnetic properties. Also, this nanocomposite has a high specific surface area (610.36 m2/g). In this article, the effect of pH, contact time, and drug concentration on DOX adsorption were investigated, and the results showed that at optimal conditions, pH = 8, contact time = 90 min, and drug concentration is 350 ppm, the adsorption capacity of MIL-101-OH/Chitosan and Fe3O4@MIL-101-OH/Chitosan are equal to 185 and 174.3 mg/g. The adsorption data follows pseudo-second-order kinetic and Langmuir isotherm models. The adsorption was physical and reversible. As a result, drug release was checked. The Fe3O4@MIL-101-OH/Chitosan exhibited a controlled release over the period of 84 h at pH 5 and reached 80 % of the DOX release rate after 60 h. In conclusion, the Fe3O4@MIL-101-OH/Chitosan composite has great potential as a drug delivery system as a result of its high adsorption capacity and magnetic properties. This research provides a promising approach for the development of novel drug delivery systems for cancer therapy. |
| format | Article |
| id | doaj-art-b36e74a56d964bb8a21d635089bb2a1f |
| institution | Kabale University |
| issn | 1873-2348 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Polymer Testing |
| spelling | doaj-art-b36e74a56d964bb8a21d635089bb2a1f2025-01-12T05:24:06ZengElsevierPolymer Testing1873-23482025-01-01142108659Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicinIman Najafipour0Nafiseh Emami1Pegah Sadeh2Adonis Amoli3Sareh Mosleh-Shirazi4Ali Mohammad Amani5Hesam Kamyab6Shreeshivadasan Chelliapan7Seyed Reza Kasaee8Ehsan Vafa9Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Chemical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, IranDepartment of Chemical Engineering, Faculty of Advanced Technologies, University of Shiraz, Shiraz, IranDepartment of Chemistry, Michigan Technological University, Houghton, MI, 49931, USADepartment of Materials Science and Engineering, Shiraz University of Technology, Shiraz, IranDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding author.Universidad UTE, Centro de Investigación en Salud Públicay Epidemiología Clínica (CISPEC), Quito, 170527, Ecuador; Department of Biomaterials, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, 600 077, India; The KU-KIST Graduate School of Energy and Environment, Korea University, 145 Anam-ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea; Corresponding author. The KU-KIST Graduate School of Energy and Environment, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea.Department of Smart Engineering and Advanced Technology, Faculty of Artificial Intelligence, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100, Kuala Lumpur, Malaysia; Corresponding author.Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranThis study reports the synthesis and characterization of a magnetic composite metal-organic framework, The Fe3O4@MIL-101-OH/Chitosan nanocomposite was used for the first time to adsorb and release the drug doxorubicin (DOX). The nanocomposite was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM). The characterization results showed that the synthesized nanocomposite has a crystalline structure and good magnetic properties. Also, this nanocomposite has a high specific surface area (610.36 m2/g). In this article, the effect of pH, contact time, and drug concentration on DOX adsorption were investigated, and the results showed that at optimal conditions, pH = 8, contact time = 90 min, and drug concentration is 350 ppm, the adsorption capacity of MIL-101-OH/Chitosan and Fe3O4@MIL-101-OH/Chitosan are equal to 185 and 174.3 mg/g. The adsorption data follows pseudo-second-order kinetic and Langmuir isotherm models. The adsorption was physical and reversible. As a result, drug release was checked. The Fe3O4@MIL-101-OH/Chitosan exhibited a controlled release over the period of 84 h at pH 5 and reached 80 % of the DOX release rate after 60 h. In conclusion, the Fe3O4@MIL-101-OH/Chitosan composite has great potential as a drug delivery system as a result of its high adsorption capacity and magnetic properties. This research provides a promising approach for the development of novel drug delivery systems for cancer therapy.http://www.sciencedirect.com/science/article/pii/S0142941824003362Metal-organic frameworkMIL101(Cr)ChitosanDoxorubicinAdsorptionDrug release |
| spellingShingle | Iman Najafipour Nafiseh Emami Pegah Sadeh Adonis Amoli Sareh Mosleh-Shirazi Ali Mohammad Amani Hesam Kamyab Shreeshivadasan Chelliapan Seyed Reza Kasaee Ehsan Vafa Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicin Polymer Testing Metal-organic framework MIL101(Cr) Chitosan Doxorubicin Adsorption Drug release |
| title | Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicin |
| title_full | Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicin |
| title_fullStr | Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicin |
| title_full_unstemmed | Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicin |
| title_short | Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicin |
| title_sort | synthesis of fe3o4 mil 101 oh chitosan for adsorption and release of doxorubicin |
| topic | Metal-organic framework MIL101(Cr) Chitosan Doxorubicin Adsorption Drug release |
| url | http://www.sciencedirect.com/science/article/pii/S0142941824003362 |
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