Multimodal Imaging of Integrin Receptor-Positive Tumors by Bioluminescence, Fluorescence, Gamma Scintigraphy, and Single-Photon Emission Computed Tomography Using a Cyclic RGD Peptide Labeled with a Near-Infrared Fluorescent Dye and a Radionuclide

Multimodal Imaging of Integrin Receptor-Positive Tumors by Bioluminescence, Fluorescence, Gamma Scintigraphy, and Single-Photon Emission Computed Tomography Using a Cyclic RGD Peptide Labeled with a Near-Infrared Fluorescent Dye and a Radionuclide

Integrins, particularly the α v β 3 heterodimers, play important roles in tumor-induced angiogenesis and invasiveness. To image the expression pattern of the α v β 3 integrin in tumors through a multimodality imaging paradigm, we prepared a cyclic RGDyK peptide analogue (LS308) bearing a tetraazamac...

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Bibliographic Details
Main Authors: W. Barry Edwards, Walter J. Akers, Yunpeng Ye, Philip P. Cheney, Sharon Bloch, Baogang Xu, Richard Laforest, Samuel Achilefu
Format: Article
Language:English
Published: SAGE Publishing 2009-03-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2009.00014
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