Spuriously low thyroid-stimulating hormone? A laboratory phenomenon
Thyroid gland is an endocrine gland with vital functions regulating metabolism, growth, and development. The tests used to assess the functions of the thyroid gland include thyroid-stimulating hormone (TSH), free thyroxine, and free tri-iodothyronine. TSH is routinely measured in the clinical labora...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-01-01
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| Series: | Apollo Medicine |
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| Online Access: | http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=4;spage=262;epage=263;aulast=Danalakshmi |
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| _version_ | 1846094499481124864 |
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| author | S Danalakshmi Mamta Soni |
| author_facet | S Danalakshmi Mamta Soni |
| author_sort | S Danalakshmi |
| collection | DOAJ |
| description | Thyroid gland is an endocrine gland with vital functions regulating metabolism, growth, and development. The tests used to assess the functions of the thyroid gland include thyroid-stimulating hormone (TSH), free thyroxine, and free tri-iodothyronine. TSH is routinely measured in the clinical laboratory with automated immunoassays to diagnose and monitor thyroid disorders. We present a case wherein the discrepancy between the clinical symptoms and the biochemical test results raised the possibility of methodological interference in laboratory testing, finally leading to a detection of a rare genetic mutation in the patient. This case reiterates that clinical correlation of laboratory results and effective communication between the clinician and the laboratory are imperative for a correct diagnosis and therapeutic interventions. |
| format | Article |
| id | doaj-art-b344c6570b6c4601875d0a76ba811bd2 |
| institution | Kabale University |
| issn | 0976-0016 2213-3682 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Apollo Medicine |
| spelling | doaj-art-b344c6570b6c4601875d0a76ba811bd22025-01-02T13:22:46ZengSAGE PublishingApollo Medicine0976-00162213-36822022-01-0119426226310.4103/am.am_81_22Spuriously low thyroid-stimulating hormone? A laboratory phenomenonS DanalakshmiMamta SoniThyroid gland is an endocrine gland with vital functions regulating metabolism, growth, and development. The tests used to assess the functions of the thyroid gland include thyroid-stimulating hormone (TSH), free thyroxine, and free tri-iodothyronine. TSH is routinely measured in the clinical laboratory with automated immunoassays to diagnose and monitor thyroid disorders. We present a case wherein the discrepancy between the clinical symptoms and the biochemical test results raised the possibility of methodological interference in laboratory testing, finally leading to a detection of a rare genetic mutation in the patient. This case reiterates that clinical correlation of laboratory results and effective communication between the clinician and the laboratory are imperative for a correct diagnosis and therapeutic interventions.http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=4;spage=262;epage=263;aulast=Danalakshmigenetic mutationsspurious resultsthyroid hormonesthyroid-stimulating hormone |
| spellingShingle | S Danalakshmi Mamta Soni Spuriously low thyroid-stimulating hormone? A laboratory phenomenon Apollo Medicine genetic mutations spurious results thyroid hormones thyroid-stimulating hormone |
| title | Spuriously low thyroid-stimulating hormone? A laboratory phenomenon |
| title_full | Spuriously low thyroid-stimulating hormone? A laboratory phenomenon |
| title_fullStr | Spuriously low thyroid-stimulating hormone? A laboratory phenomenon |
| title_full_unstemmed | Spuriously low thyroid-stimulating hormone? A laboratory phenomenon |
| title_short | Spuriously low thyroid-stimulating hormone? A laboratory phenomenon |
| title_sort | spuriously low thyroid stimulating hormone a laboratory phenomenon |
| topic | genetic mutations spurious results thyroid hormones thyroid-stimulating hormone |
| url | http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=4;spage=262;epage=263;aulast=Danalakshmi |
| work_keys_str_mv | AT sdanalakshmi spuriouslylowthyroidstimulatinghormonealaboratoryphenomenon AT mamtasoni spuriouslylowthyroidstimulatinghormonealaboratoryphenomenon |